Protein Alignment NLGN1 and Jhedup

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 688
• Identity: 180/688 - (26%)
• Similarity: 271/688 - (39%)
• Gaps: 185/688 - (26%)

Human    35 GCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQ------FLGVPYAAPPTGER 93
            |.||.....:...||    :...:.|.:||        .|.|..|      |:|:|:|.||.|..
  Fly     7 GVLLFVAVAVGDSLD----VCLEDMGCMRG--------TLMPGYQSGEFEAFMGIPFAQPPVGPL 59

Human    94 RFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNI 158
            |.:.|.|..||..:.:|......|.|.            .:|.....::.      .|||||||:
  Fly    60 RLKNPVPNEPWEGVLDAGAAKDSCIQR------------SYFAKEWGLMG------VEDCLYLNV 106

Human   159 YVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGN-LYDG-SVLASYG 221
            |.|                .:.|||:        .|||||||||.:..|:.: :..| ..|....
  Fly   107 YRP----------------KNRAEDK--------LPVMVYIHGGGFFSGSAHPMASGPEYLMDTN 147

Human   222 NVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSC 286
            .|:::|:|||||..|||||||:...||:|..|...||:|..::|..|||||.::||.|..|||..
  Fly   148 KVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGIS 212

Human   287 VNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTA-LSSWAVSFQPAKYARMLATKVGCNVSDTV-- 348
            .:|..:         |.::|||||.:::.:||. ||:..:...|...||.|..::..:.::::
  Fly   213 AHLHMI---------SPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSS 268

Human   349 -ELVECLQKK-PYKELVDQD---IQPARYHIAFGPVIDGD----VIPDDPQILMEQGEF--LNYD 402
             :|.|.|:.. |.|.||..|   :.....|:...||::..    .:.:||......|..  :.:.
  Fly   269 QDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWI 333

Human   403 IMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDN---LYGYPEGKDV-LRETIKFMYTDW 463
            :.|....|||..|:.....:..  ..::|:   .||:::   |...|||..| :...|...|...
  Fly   334 LSLSSRAGEGSLFIMRAFINPK--LRAEFN---ENFLEHMALLLNLPEGTPVQMVSEILDAYDFK 393

Human   464 ADRHNPETRRKTLLALFTDHQWVAPAVAT-------ADLHSNFGSPTYFYAF----------YHH 511
            .|..|.:|..| |..:..|..:..|...|       |:|..|   |.:.|.|          :..
  Fly   394 GDSLNNDTMLK-LAEISGDFNFYYPIYETISSYVTYANLEEN---PLFIYIFEFAGLNSITKFFA 454

Human   512 CQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 576
            ..||..  ...|.|.|:..:.:.||:  ..:.||.:  ..|..:...:.:..|:|||||
  Fly   455 GTTDDY--GLGAVHMDDGLHTIRIPV--SFDDFPKD--SEDAKVIQRMSSLMTDFAKTG------ 507

Human   577 PQDTKFIHTKPNRFEEVAWTRYSQ-KDQ---LYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLN 637
                        .|.|.:..:.|. |:|   .|||.|..   ||.|                 |.
  Fly   508 ------------VFHEESICKVSDFKEQGMCNYLHFGGN---KEKY-----------------LE 540

Human   638 DISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQ 675
            ||                     :||:.:| |||..|:
  Fly   541 DI---------------------RNSITLT-AFPIWKK 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	165/620 (27%)
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	152/568 (27%)