Protein Alignment NLGN1 and CG12869

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 168/745 - (22%)
• Similarity: 284/745 - (38%)
• Gaps: 182/745 - (24%)

Human    75 GPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQ--NII-----DGRLPEVMLP 132
            |.|..|||:|||..|..|.||.|.:|.|.::....||...|:|||  |.|     ||.:|..:
  Fly    50 GAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSV-- 112

Human   133 VWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSG---GPKP 194
                           ...||||||||:.|                          :||   |..|
  Fly   113 ---------------STDEDCLYLNIWTP--------------------------ESGMRYGKLP 136

Human   195 VMVYIHGGSY-MEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQ--AAKGNYGLLDLIQ 256
            ::|.:.|..: .:...|..:|..||..| ::|::|.||..:.|:||.|:|  ...|||||.|:..
  Fly   137 IVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQM 200

Human   257 ALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL-TLSHYSEGNRWSNSTKGLFQRAIAQSGTAL 320
            ||||...|...|||:|..||:.|.|:||:.:.|: ||...|:..:....:.|...||:.|:.
  Fly   201 ALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNH--- 262

Human   321 SSWAVSFQPAKYARMLATKVGCNVSDTV--ELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGD 383
            ..|.|     :..::|..|:||...:..  :|:.||::|..::|:  ....:.|:...|....|.
  Fly   263 QKWIV-----ETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNGSSQLGV 320

Human   384 VIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDN---- 441
            ::|:.  :.:|| ...|.   .::||:...||....:..:|     .|.:...|:..::::
  Fly   321 ILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLD-----VAREGQVALHKYINHTLLP 377

Human   442 -----LYGYPEGKDVLRETIKFMYTDWADR---HNPETRRKTLLA----LFTDHQWVAPAVATAD 494
                 |....|........|::.|.:....   |        |||    |.::..:..|.....:
  Fly   378 NVMRALESVGEESSTQLAAIRWRYFNGKGEGVSH--------LLAGMQRLLSESLYELPYSRILE 434

Human   495 LHSNFGSPTYFYAFYHHCQTD---QVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLS 556
            |.:  |:.:|.|.|.|....|   :...:..|:|..::|.:||..:.  .::....||..:..|.
  Fly   435 LLN--GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLF--QQIARRRFSGEEEQLC 495

Human   557 AVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRAN 621
            ..:...:.||.|.|:|.             |.|..: .|..|::::.....:|.:.:..:....:
  Fly   496 RKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKENPFVYSLGEQAKTPQTGSVD 546

Human   622 KVNLWLELVPHLHNLNDISQYTSTTTKVPSTD---------ITFRPTRKNSVPVTS--------- 668
            :.              ::.:.....|..|..|         .|:|....||...::
  Fly   547 EA--------------EVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNH 597

Human   669 ----------AFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIA---------VGASLLFLNILAF 714
                      ..|..:::|.:   ...::.||....|.|...|         :|...|.|..|..
  Fly   598 LQMVYGFWQVLMPLEREEDLR---GGGALGQRVRLLEASADAARYRQGFYAMLGLVCLLLACLCL 659

Human   715 AALYYKKDKRRHDVHRRCSPQRTTTNDLTH 744
            .....|:|.  :.:.||.:...:....| |
  Fly   660 CVYLLKRDP--NAMRRRSASSASDCYSLXH 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	144/588 (24%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/578 (25%)