Protein Alignment NLGN1 and CG4382

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Alignment Length: 677
• Identity: 184/677 - (27%)
• Similarity: 282/677 - (41%)
• Gaps: 164/677 - (24%)

Human    12 VWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKL-DDVDPL----------VATNFGKIRG- 64
            :||   .|      |..|.||.|.....:...||:.: |:.||:          :.|..|||||
  Fly     1 MWR---LC------GFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT 56

Human    65 -IKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPE 128
             :..:.......    |.|:|||.||....|||||||...|.|..:||...|.|||
  Fly    57 ILPSQSGRNFYA----FRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ--------- 108

Human   129 VMLPVWFTNNLDVVSSYVQDQSEDCLYLNIY---VPTEDGPLTKKQTDDLGDNDGAEDEDIRDSG 190
                      |.:||.   |.|||||.:|||   :|:|..|                  ::|
  Fly   109 ----------LGLVSG---DVSEDCLRVNIYTKELPSESQP------------------NVR--- 139

Human   191 GPKPVMVYIH-GGSY-MEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLD 253
              :||:|:|| ||.| :.|....:.|........::::|.|||||.||||:||.:.|.||.||.|
  Fly   140 --RPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKD 202

Human   254 LIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGT 318
            .:|.|||...:|..|||||..||:.|.|||...|.|..:|..|         :|||.:||..||.
  Fly   203 QVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMS---------RGLFHKAIVMSGA 258

Human   319 ALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYH-------IAF 376
            ....|::.......|...||.:.|:..:..|:::||:.|.|.|..  :..|..:.       |.:
  Fly   259 VTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFA--NTLPKMFEFDRNNPLILW 321

Human   377 GPVIDGD-----VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFA-- 434
            .|||:.|     .:.::|....:..:|:...|:.|:.:.|.:....:|:.|...:||.:.:|.
  Fly   322 KPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESL 386

Human   435 ----------------VSNFVDNLYGYPEGK-DVLR--ETIKFMYTDWADRHNPETRRKTLLALF 480
                            :|..:.|.| :|:.. |..|  |.:..:|:|             .|..|
  Fly   387 APVFFMYNTSDARACNISQELRNHY-FPDKLIDANRSLEALSNLYSD-------------ALTGF 437

Human   481 TDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHG----DEVPYVLGIPMIGPT 541
            ..|::|..|..:        :..|:|.|.:......:....||.:|    |::.|:...|.|...
  Fly   438 GIHRFVHLAARS--------TKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVEPSISRM 494

Human   542 ELFPCNFSKND--VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQL 604
                  |:::|  ..:..:::..::.||..||||:|...          ...::.|..:|.|.:.
  Fly   495 ------FTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDL----------ALRDIRWRPFSFKKRY 543

Human   605 YLHIGLKPRVKEHYRANKVNLWLELVP 631
            ||.||....::|:..|....:|..|.|
  Fly   544 YLDIGKHITLEENLNAENYEIWKRLFP 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	170/629 (27%)
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	168/620 (27%)