Protein Alignment NLGN1 and CG3841

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 176/639 - (27%)
• Similarity: 265/639 - (41%)
• Gaps: 148/639 - (23%)

Human    29 LTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRG-IKKELNNEILGPVIQFLGVPYAAPPTGE 92
            ||..:|  |:..|...:......||:|..:.|:|:| ..:...|:   .:..|.|:.||..|.|:
  Fly     7 LTWALL--LILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNK---TIYAFRGIRYAQSPVGQ 66

Human    93 RRFQPPEPPSPWSD-IRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYL 156
            .||..|.|.:.|.| :.|||..:.||||       |.|                |...|||||.:
  Fly    67 LRFANPVPETSWGDEVFNATSDSLVCPQ-------PGV----------------VSLMSEDCLKI 108

Human   157 NIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASY- 220
            |::        ||...|..                  |||||||||:.:.|:|:       :||
  Fly   109 NVF--------TKSFEDKF------------------PVMVYIHGGANVLGSGH-------SSYE 140

Human   221 --------GNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITV 277
                    .:|:.:..|||||.||||||.....|||:|.||.:.||.|..::|..|||||..:|:
  Fly   141 AGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205

Human   278 FGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVS--FQPAKYARMLATKV 340
            .|..||...|:|...|..|         .|||.|||..||:|.:.:.:.  |    :.|.||.::
  Fly   206 IGISAGSMAVSLHLASPLS---------AGLFHRAILMSGSATNHFDIDNLF----WTRKLAREL 257

Human   341 GCNVSDTVELVECLQKKPYKELVDQDIQPARYHIA---FGPVIDGDVIPDDPQILMEQGEFLNYD 402
            ||.:.|..::||||:.:.:..:|:.......|.:.   :...|||..:.:.|..|:::|.|....
  Fly   258 GCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVP 322

Human   403 IMLGVNQGEGLKFVENIVDSDDGISASD----FDFAVSNFVD---NLYGYPEGKDVLRETIKFMY 460
            ::        :.|..|..|.:..:...:    .||| |||||   .|:.|.....:..:...|..
  Fly   323 LL--------ISFTANEFDYNANVHLENQHLLHDFA-SNFVDYAPELFLYRHDAQIGEKLKDFYL 378

Human   461 TDWADRHNPETRRKTLLALFTD-------HQWVAPAVATADLHSNFGSPTYFYAF-YHHCQTDQV 517
            .|.....|.| ..:....:|:|       |:.|       .|.|:| :|.|:... |...|:...
  Fly   379 GDNTTEINSE-NIENFGQIFSDAYIGHGVHRLV-------QLASHF-TPVYYTRMDYVGDQSLSA 434

Human   518 PAWAD-----AAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVP 577
            |...:     ..|.|::.|||.....||  |...|.|  ||.:...:.:::|:|||||.|.....
  Fly   435 PLNGENKPVGVGHADDLHYVLPGYWYGP--LMAANDS--DVFMMERLTSWFTHFAKTGTPLNSTD 495

Human   578 QDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVP 631
                            .|...:......|:.|:..:|.....:|:..:|.:|.|
  Fly   496 ----------------IWPPCNSTVLKMLYNGVVTQVGSPGYSNRYAVWDKLFP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	168/609 (28%)
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	168/610 (28%)