Protein Alignment NLGN1 and CG9289

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_609245.1
• Gene: CG9289 / 34195
• FlyBaseID: FBgn0032058
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 646
• Identity: 169/646 - (26%)
• Similarity: 263/646 - (40%)
• Gaps: 161/646 - (24%)

Human    52 DPLVAT----NFGKIRGIKKELNNEILG-PVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNAT 111
            :|.|.|    :.|::||  :.|..:..| .::|||.:||..    ..||:|.||...|..:..|.
  Fly    72 EPKVFTTTVPDLGRLRG--RTLTTDWTGQKIMQFLDIPYGK----AERFRPAEPAPSWKGVLPAH 130

Human   112 QFAPVCP---QNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTD 173
            :....||   ..|:..:|.|        :..||         ||||.|::.....:|.
  Fly   131 RPHAGCPSIQDLIVFAKLEE--------DGFDV---------EDCLRLSVNTKAMEGK------- 171

Human   174 DLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDG-SVLASYG-----NVIVITVNYRL 232
                              ..||||||||..:       ||| ||.|:.|     :|::::|.|||
  Fly   172 ------------------SLPVMVYIHGDFF-------YDGDSVEAAPGYLLEHDVVLVSVRYRL 211

Human   233 GVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSE 297
            |..|||||......||..:.|:|.||:|..::|..|||||.|:|:||...|.:.||:||||
  Fly   212 GPFGFLSTLTDEMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLS---- 272

Human   298 GNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV-ELVECLQKKPYKE 361
                .....|||.|.|.|||||||...::..|....:.:....||..|..| :|.:||.:.....
  Fly   273 ----PAVPAGLFHRVIYQSGTALSPAFITDAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATM 333

Human   362 L-----VDQDIQPARYHIAFGP---VIDG--DVIPDDPQILMEQGEFLNYDIMLG-VNQG----- 410
            |     |..:.||:....|:|.   ||.|  .::|:.|..|:...:|..|..|.| |..|
  Fly   334 LLAAFSVHGENQPSLSGGAYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFML 398

Human   411 -----------------EGLKFVENIVDSDDGI--SASDFDFAVSN-FVDNLYGYPEGKDVLRET 455
                             .|.::::.|::..:|.  |.|..:|:... |..|        ||...|
  Fly   399 RDIFADIFNETILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQN--------DVKNGT 455

Human   456 IKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAW 520
            .|.:.....|..:..:.:..:|.:...:....|            :.||.|:|.:..:.::....
  Fly   456 FKRLTPGLIDLCSTISLKNPVLLVLQANAKKLP------------NSTYLYSFDYEGEQNRYATG 508

Human   521 ADAAHGDEVPYVLGIPM------IGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQ 578
            .|.|  :.||:.:|:.:      :.|...|....|..|:.::..::..||:||.||.|..| :|
  Fly   509 EDEA--NFVPFDMGVSLTDDNLYLFPWPRFLALNSNRDLKVARRMVALWTSFATTGVPQAPGLP- 570

Human   579 DTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNL-ND 638
                           ||...:.:...|:.|.......::| .::..:.:|...|.:|| ||
  Fly   571 ---------------AWPAMNDETGPYMKIDRTVSFGDNY-LDEYRIAVEEAKHGYNLVND 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	163/631 (26%)
CG9289	NP_609245.1	COesterase	71..598	CDD:395084	163/627 (26%)