Protein Alignment NLGN1 and CG9287

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_609244.1
• Gene: CG9287 / 34194
• FlyBaseID: FBgn0032057
• Length: 625
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 159/574 - (27%)
• Similarity: 239/574 - (41%)
• Gaps: 130/574 - (22%)

Human    49 DDVDPLV-ATNFGKIRG-------IKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWS 105
            ::.|.:| ....|.|:|       .|:|        |:||:.|.||.||||..||:.|.|..||.
  Fly    30 EEKDTIVELPTLGSIQGKILETAWTKRE--------VLQFVDVRYAEPPTGLHRFKAPRPIEPWE 86

Human   106 DIRNATQFAPVCPQNI-IDG--RLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPL 167
            |:.:||.....||..: :|.  ||.:|         |||         ||||.:.|..|.....|
  Fly    87 DVMDATAEKIGCPSVVSMDSLRRLDDV---------LDV---------EDCLTMTITTPNVTSRL 133

Human   168 TKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRL 232
                                      ||:|||||....||:.:......|.. .:|:::|..|||
  Fly   134 --------------------------PVLVYIHGEYLYEGSNSEAPPDYLLE-KDVVLVTPQYRL 171

Human   233 GVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSE 297
            |..|||||......||.|.||:..||::....|.:|||||.|:||.|...|.:..:|||||...:
  Fly   172 GPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQ 236

Human   298 GNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKEL 362
                    :|||.:.|..||:|:....:...|.|:|:.:|.|..|.:....:|..||.:....||
  Fly   237 --------RGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALEL 293

Human   363 VDQDIQPA--------------RYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGL 413
            :...::.|              ::.|. ||   ..|:|..|..||.:..| :|..|.|..:..|.
  Fly   294 LTAFMEHALEKSDLGIGHTGGIQFTIG-GP---SGVLPKHPYDLMLETNF-SYPAMGGCPKNAGS 353

Human   414 KFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRR-KTLL 477
            :.:..|||:|......|.::...|::|::.....|.|.......|:..|:.:|:..|... .||:
  Fly   354 RVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTFDTLI 418

Human   478 ALFTD------HQWVAPAVATADLHSNFGSP--TYFYAF--------YHHCQTD---QVPAWADA 523
            ....|      |:  .|.:...:: :|..:|  |:.|:|        |.....:   |.|..|..
  Fly   419 PRLIDVAGTLNHK--LPVLLALNM-NNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGV 480

Human   524 AHGDEVPYVLGIPMIGPTELFP-----CNFSKNDVMLSAVVMTYWTNFAKTGDP 572
            :..||..|           |||     ...|:.|..::..::..||||..:|:|
  Fly   481 SLTDEALY-----------LFPYPEHVTRLSRPDQSMAHRMVELWTNFVISGNP 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	159/571 (28%)
CG9287	NP_609244.1	COesterase	33..558	CDD:395084	159/571 (28%)