Protein Alignment NLGN1 and Glt

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Alignment Length: 768
• Identity: 194/768 - (25%)
• Similarity: 287/768 - (37%)
• Gaps: 216/768 - (28%)

Human    56 ATNFGKIRGIK--KELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118
            |...|:|.||.  |.:.|.   ||..|||:.|.....|..|||..:|......: |||..:|.|.
  Fly    64 APEVGQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCA 124

Human   119 QNIIDGRLPEVMLPVWFTNNLD--VVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGA 181
            |      .||          ||  .:|....:..:|||.|:||.|                 :||
  Fly   125 Q------FPE----------LDRLRLSESRGENVDDCLTLDIYAP-----------------EGA 156

Human   182 EDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGS--------VLASYGNVIVITVNYRLGVLGFL 238
            ..         .||:|::||..       |:||.        ||..  :|:::::||||...|||
  Fly   157 NQ---------LPVLVFVHGEM-------LFDGGSEEAQPDYVLEK--DVLLVSINYRLAPFGFL 203

Human   239 STGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSN 303
            |.......||..|.||..||.|...|:..|||:..::|:.|...|.:..:.|:||..: ||
  Fly   204 SALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRA-GN---- 263

Human   304 STKGLFQRAIAQSGTALSSWAVSFQP-------AKYARMLATKVGCNVSDTVELVECLQKKPYKE 361
                |||:.|.||||||:.:.:..||       |:.||.....:..:......|.:||.:.|..:
  Fly   264 ----LFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQ 324

Human   362 LVD--QDIQPARYHIAFG-----PVIDGD---VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV 416
            ||.  :.:.....|:...     .::.||   .:|..|..|..... |...:::|..:......|
  Fly   325 LVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSS-LALPMIIGATKDASAFIV 388

Human   417 ENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETI----KFMYTDWADRH---------- 467
            ..|.|....:.:.:    ||:::|         .|||.|.    ..::..||.|.
  Fly   389 SRIYDQLARLQSRN----VSDYID---------VVLRHTAPPSEHRLWKQWALREIFTPIQEQTA 440

Human   468 NPETRRKTLLALFTDHQWVAPAVATADLHSNFGS-PTYFYAF----YHH---CQTDQVPAWADAA 524
            :.:|....||.|.....:.||.:.:  :..::.| |.|.|.|    .||   ..::.:|...||:
  Fly   441 SLQTVAPGLLELSNYILYRAPVINS--ISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDAS 503

Human   525 HGDEVPYVLGIPMIGP--TELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV---PQDTKFIH 584
            ..|:..|:...|   |  :.|.|.     |..||..::|.|.|||.||.||...   ||.|.
  Fly   504 LSDDSVYLFPYP---PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNPSSGVWPQATS--- 557

Human   585 TKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKE-----HYRANKVNLWLELVPHLHNLNDISQYTS 644
                  |...:.|::...|..|.  |.|...|     :||          |.:....|.....|:
  Fly   558 ------EYGPFLRFTNNQQSPLE--LDPHFGEGIYLPNYR----------VIYKPTTNFSPPITT 604

Human   645 TTTKVPSTDITFRPTRKNSVPVTSAFPTAK-QDDPKQQ-PSPFSVD----------QRDYSTELS 697
            |||...:|..|.||...|        |.|. |:.|.|| |:....|          |:::..|
  Fly   605 TTTTTTTTTTTSRPYAYN--------PYANWQNRPSQQHPNWHPADPEYVRAQEARQQEFIRE-- 659

Human   698 VTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEI 750
                                   :::||.:...| ..||....:....|:|.|
  Fly   660 -----------------------REQRRREQQLR-DQQRYPQQEPREQQDERI 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	165/630 (26%)
Glt	NP_477504.1	COesterase	58..579	CDD:395084	162/613 (26%)
		Casc1_N	681..>717	CDD:464947	3/8 (38%)