Protein Alignment NLGN1 and Nlg2

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Alignment Length: 872
• Identity: 267/872 - (30%)
• Similarity: 387/872 - (44%)
• Gaps: 254/872 - (29%)

Human    55 VATNFGKIRGIKKELNNEILGPVIQ-FLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118
            |.|.:|.:|||....:     |::: |||:|||:||.|..||.||..||.|..:|:|.:|:||||
  Fly   185 VKTKYGLLRGIVVRSS-----PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCP 244

Human   119 QNI-IDGRLPEVMLPVWFTN--NLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQ---TDDLGD 177
            ||| |....||.:|.|....  .|..:...:::|||||||||||||.|    |::|   |||
  Fly   245 QNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE----TRRQRRNTDD--- 302

Human   178 NDGAEDEDIRDSGGPK---PVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239
                      .:|.||   ..:|:|||.||...:||.||||.||::|||||:|:|:|||:.|||.
  Fly   303 ----------TTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLK 357

Human   240 T-GDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSN 303
            | |.::|:||:||:||:..|.|..||:..|||||..||:.|.|.|....|:|.:|..:
  Fly   358 TGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVA------- 415

Human   304 STKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV--ELVECLQKKPYKELVDQD 366
              ..|.||.:..||:|||.||:...|....|.:|.:.||: .|.:  :|..||:.|...||:...
  Fly   416 --SDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCH-GDMLYDDLAPCLRTKSVAELLAVK 477

Human   367 IQPARYHIAFGPVIDGDVI------------PDDPQILMEQG-EFLNY---DIMLGVNQGEGLKF 415
            :...|:.:.|.|.:||.||            |....|:...| |:.|:   |::.      .|..
  Fly   478 VDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIF------CLTS 536

Human   416 VENIVDSDDGISASDFDFA---------VSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR-H 467
            ||:.:|    :||.|.:|.         :..||.|.:.|.     |.|   .:|..||||... .
  Fly   537 VESYLD----LSAQDLEFGFNETRRDRILRTFVRNNFHYH-----LNEIFAVLKNEYTDWEKAIR 592

Human   468 NPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYV 532
            ||.:.|...|...:|....:|.:....:||..|...||..|.|....::.|..:.:..|::||:.
  Fly   593 NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFW 657

Human   533 LGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---- 584
            ||:||   :.|||.|::..:..:..:::.|.:||||||:|||       |.|.:.  ..:|
  Fly   658 LGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKK 719

Human   585 -----TKPN------------------------------RFEEVA-------------------- 594
                 |.||                              |..:.|
  Fly   720 RSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDEL 784

Human   595 --WTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH---NLND---------------- 638
              |..|...:|||:.:|.|..::.|||.:|:::||.|:|.||   |:||
  Fly   785 PFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRD 849

Human   639 ---------------------ISQYTSTTT-----KVPSTDITFRPTRKNSVPVTSAFPTAKQ-- 675
                                 |.|.:.|||     |.|||:.|     :...|:.:..||..:
  Fly   850 LYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNAT-----QALNPLGTGTPTTTECG 909

Human   676 -------------DDPKQQPSPF-SVD-QRD-------------------------YSTELSVTI 700
                         ..||...:.. .|: |:|                         |:|.|..|:
  Fly   910 IDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATV 974

Human   701 AVGASLLFLNILAFAALYYKKDKRRHD 727
            |||..||.||:|.||.:|::::||..|
  Fly   975 AVGCFLLILNVLIFAGIYHQREKRARD 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	222/682 (33%)
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	208/593 (35%)