Protein Alignment NLGN1 and CG5397

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 156/628 - (24%)
• Similarity: 249/628 - (39%)
• Gaps: 157/628 - (25%)

Human    52 DPLVATNF----GKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQ 112
            ||::....    .::.|.:    |...| :..|||:.||.||.|..|:..|.......|. |||:
  Fly    49 DPVIFARLFDRDARVEGFR----NPSTG-IYSFLGMHYAEPPVGPLRYSRPVYKRLAGDF-NATK 107

Human   113 FAPVC-------PQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKK 170
            ..|.|       ||.||.                          .||||.||:|.|
  Fly   108 HGPPCIQPHPQFPQRIIG--------------------------DEDCLLLNVYTP--------- 137

Human   171 QTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVL 235
                          .:.|.....||.|:||.|.|..|:...||.:.:|..| .||:...||||.|
  Fly   138 --------------QMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSL 187

Human   236 GFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNR 300
            |.:..|.:...||..:.||..||||.::.|.:|||:|.::...|.|:|.:....|::|..|   |
  Fly   188 GIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTS---R 249

Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELV-- 363
            .:....|:    :|.||||||.:|:..:|.:..:.:|...||...:.:|:|.||:.|..::::
  Fly   250 SAGDVHGV----VAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKN 310

Human   364 DQDIQPARY-----------HIAFGPVI----DGDVIPD----DPQILMEQGEFLNYDIMLGVNQ 409
            |..:|..|.           ::.|.|.|    ||..:|.    :|:..::...|....::.||.:
  Fly   311 DDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTK 375

Human   410 GE-----GLKFVENIVDSDDGI--SASDFDFAVSNF--VDNLYG------YPEGKDVLRETIKFM 459
            .|     .::.:|.:..|.:..  |.||....:::|  :|.|.|      .|....||..|::.:
  Fly   376 HETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDV 440

Human   460 YTDW--ADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQ------ 516
               |  ....|.:.....::...||..:..|||.|..:.|.. :|.:.|:|.::....:
  Fly   441 ---WKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLK 501

Human   517 -VPAWADAA--------HGDEVPY------VLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNF 566
             :|..::.|        ||||:.|      :.|.|| ..|.|    .|..|:.:...::.....|
  Fly   502 GLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPM-EETRL----TSAEDLKVRNNLIDLLVKF 561

Human   567 AK---------------TGDPNQPVPQDTKFIHTKPNRFEEVA 594
            |.               ||.....:..|||...:...||.|::
  Fly   562 ANKDKEEGGKSSIFQSVTGKATPFIKIDTKLQTSNDFRFCELS 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	156/628 (25%)
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	153/621 (25%)