Protein Alignment NLGN1 and CG6414

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 186/612 - (30%)
• Similarity: 267/612 - (43%)
• Gaps: 142/612 - (23%)

Human    80 FLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSS 144
            |:|||||.||..:.||:||.|.:||...|.|.:.||:|.|     |.|       |..::
  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ-----RDP-------FRRDM----- 103

Human   145 YVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTG 209
             :.:.||||||||:|.|  :.|.|                     .|..||||:.|||.:..|:|
  Fly   104 -ILEGSEDCLYLNVYTP--ERPRT---------------------NGSLPVMVWFHGGGWQCGSG 144

Human   210 --NLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDP 272
              :.|....|..: ::::::.|:|||.||||||......||.||.|.::.|.|...||..|||||
  Fly   145 ISSFYGPDFLLDH-DIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDP 208

Human   273 LRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAK------ 331
            ..:||||..|||:.|....||..|         :||..|.||||||..:.||   |||.
  Fly   209 NSVTVFGESAGGASVTYHMLSEKS---------RGLLHRGIAQSGTYFNPWA---QPAHKGVAAG 261

Human   332 YARMLATKVGC-NVSDTVELVECLQKKPYKELVDQ-------DIQPARYHIAFGPVI----DGDV 384
            .|..||..||| |..:..|.:|||:|||.:::|..       |..|.   |.|.||:    ||..
  Fly   262 RATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPM---IPFPPVVEPEHDGAF 323

Human   385 IPDDP-QILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEG 448
            :...| |.....|  |...:|:|....|||.....:::....:  ::|.......:..:..|...
  Fly   324 LTVAPRQAAKPHG--LQLPLMVGATAEEGLLKTAALLNLPQLL--AEFKSQFEQVLPVVLNYDHH 384

Human   449 KDVLRETI-----KFMYTDWADRHNPETRRKTLLALFTDHQWVAP-------AVATADLHSNFGS 501
            .|.:|:||     .|.:....|  ..:...:.|..|.:|..:||.       .::..|:     :
  Fly   385 DDSVRQTITQRIESFYFKSGHD--YDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDV-----A 442

Human   502 PTYFYAFYHHCQTDQVPAWA-------DAAHGDEVPYVLGIPMIGPTELF----PCNFSKNDVML 555
            |||.|.|.|.........:.       .|.|.:|:.|:..|    ..|||    |   ::.|:.|
  Fly   443 PTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLEL 500

Human   556 SAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKP-------R 613
            ..:::..|.:|||||:||   |.:..| |. ||      |:..|.....:..:|.|.       |
  Fly   501 RELMLHLWVSFAKTGNPN---PTNVSF-HL-PN------WSPASSYPVEFARLGTKMEDSASIFR 554

Human   614 VKEHYRANKVNLWLELVPHL-----HN 635
            ::.....::|:.|.:|.|||     ||
  Fly   555 LENELMQHRVDFWRDLQPHLPASHAHN 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	179/596 (30%)
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	179/596 (30%)