Protein Alignment NLGN1 and clt

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 184/608 - (30%)
• Similarity: 271/608 - (44%)
• Gaps: 136/608 - (22%)

Human    54 LVATNF------------GKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSD 106
            |:.|.|            |.:.|.:|:|.|.:  ....|||||||.||.||.||:.|.|
  Fly     9 LIFTRFCSSMKVKVPVKQGVLVGRQKKLVNGL--EYNSFLGVPYAEPPVGELRFRSPRP------ 65

Human   107 IRNATQFAPVCPQ--NIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTK 169
            :....:....|.:  |:...|.|       ||  |:|..      |||||:||:|.|
  Fly    66 LERFQKQELDCSKEGNVSYQRDP-------FT--LEVAG------SEDCLFLNVYAP-------- 107

Human   170 KQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNL---YDGSVLASYGNVIVITVNYR 231
                           .::.:..|.||||:||||.:..|.||.   :...::..  .|||:|:|||
  Fly   108 ---------------KVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQ--EVIVVTLNYR 155

Human   232 LGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYS 296
            ||.|||||..::...||.||.|...||.|..|||..|.|||..:|:||..||||.|:|.|.:.::
  Fly   156 LGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHA 220

Human   297 EGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ---PAKYARMLATKVGCN--VSDTVELVECLQK 356
                     |.||.:||.|||||...|.  ||   ||| .|.||..:|..  ..|:..|:..||.
  Fly   221 ---------KRLFHKAIMQSGTANMEWV--FQNEAPAK-TRRLAELLGGGDFGGDSKALLTFLQS 273

Human   357 K---PYKELVD--QDIQP--ARYHI--AFGPVIDGDVIPD-----DPQILMEQGEFL-NYDIMLG 406
            :   |...|.:  :.:.|  .|.|:  ||.||::....||     |...||.:.:.| :..:::|
  Fly   274 EKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMG 338

Human   407 VNQGEGLKFVENIVDSDDGISASDFDFA---VSNFVDNLYGYPEGKDVLRETIKFMYTDWA-DRH 467
            .|..|||..|   |.:...:.|.:.|.|   ..|.|.:... ||.::...:...|.:...| .:.
  Fly   339 YNSAEGLAIV---VKAKQKLEAYEDDLARLVPRNLVLDPQA-PEAQEAASDIRAFFFNGQALSKE 399

Human   468 NPETRRKTLLALFTDHQWVAPAVATADLHSN--FGSPTYFYAFYH------HCQTDQVPAWADAA 524
            |.:    .|:.||:|:.:........::|::  ..||.|||...:      :.:..|.......|
  Fly   400 NMD----NLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVA 460

Human   525 HGDEVPYVLGIPMIG-PTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPN 588
            |.|::.|:  ..|.| .||:     :::|:|::..:...|.|||:.|.|: |:.:..|    ||:
  Fly   461 HADDICYL--FQMAGDETEM-----NRDDLMVTERLCEMWANFARDGKPS-PIWKPVK----KPH 513

Human   589 RFEEVAWTRYSQKDQLYLHIGLK 611
            ..|.:      |.|.|.:...||
  Fly   514 NGEPI------QLDCLLIDRELK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	184/608 (30%)
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	181/595 (30%)