DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASTKD2 and CG31643

DIOPT Version :9

Sequence 1:	NP_001129665.1	Gene:	FASTKD2 / 22868	HGNCID:	29160	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	169/863 - (19%)
Similarity:	295/863 - (34%)	Gaps:	282/863 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    45 CLGLCKPKIVHS---NWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALRIERL 106
            |.||....:|..   .|||   :|:..|::       :||...:..:....|....:..|.|:.|
  Fly    95 CDGLQSSHVVMGISLLWNI---YHDAEQAS-------KDAITDRVLLNVLPKLAPYVHQLEIDDL 149

Human   107 ----LYAKRLFFDSKQSLVPV----------DKSDDEL--------KKVNLNHEVSNEDVLTKET 149
                ||.:::...:.:::|..          .:.|||:        ..|.:|.|   .|..|...
  Fly   150 SRCYLYLRKMHIPNSEAVVEAVLTRSLQLIESQVDDEVIPLTSLSRLSVGINLE---RDFFTPLV 211

Human   150 KPN-------RISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLM 207
            ..|       .|:..:.:|:...||..|              |...:.|.:.|.   .||:.||
  Fly   212 CRNFIPHLEHHINWCRSAEQVRLLSTCL--------------FQLHFLIDEELF---TRFKLRL- 258

Human   208 FSHPAFNQLCEHMMREAKIMQY--KYLLFSLHAIVKLGIP----QNTILVQTLLRVTQERINECD 266
                      ..||:...:...  |.||..:|   .|.||    .:|.|::.::.|.:..|::.:
  Fly   259 ----------TEMMQSGVLSSETPKALLKVIH---MLNIPVWSQTHTQLIREVMLVLRPCIHQME 310

Human   267 EICL-SVLSTVLEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLE 330
            ...| |:..|.|...||...:..|:.....|:.::       .|...:...:....|  |:|...
  Fly   311 SADLKSICRTFLHHQEPAALIEPLKKALEKLLQEE-------GTADALFCAVPFATP--LQRDQY 366

Human   331 MKALREL----DRFSVLN-SQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLR-IMINILQSC 389
            :...:||    :.:...| |.|:|.||.|:....:...:.....|:..:..||.: :.:..|:.|
  Fly   367 LHQFKELLYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHLHLRFLRHC 431

Human   390 KDLQ---------YHNLDL-----------------------FKGLADYVAA---TFDIW-KFRK 418
            :...         |.:|:|                       |..||.:|.|   |...| ||..
  Fly   432 QRYMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKKFPN 496

Human   419 VLFILILFENLGFRP-VGLMDLFM------------------------------------KRIVE 446
            .|    |.:.|...| :|:.|.|:                                    :|.:.
  Fly   497 FL----LSKMLAMAPQLGIQDCFLLSRGMQIASELRFRQHLPALAGMQLSTMDSILIGCAERHLR 557

Human   447 DPES--LNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLMN 509
            |.|.  ||...:..|:.|   |:|..|.:|...:.:.:|.....:.:.::|..:.|..|:|...|
  Fly   558 DAEKDPLNASELSMIVRT---LSHRKKLKNTVVYNQALAQYKNLHCNDLNSRVVRDMAYNFNASN 619

Human   510 YFPLAPFNQLLQK--------------DIISELLTSD----------------------DMKNAY 538
            :|  .|  :||:.              |.:.::||..                      |.....
  Fly   620 FF--VP--ELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMPASVEALNHASEVLLRDFDQMS 680

Human   539 KLHTLDTCL-----------------------KLDDTVYL-------------------RDIALS 561
            .|..:..||                       :::|.:.:                   |.:.|.
  Fly   681 GLSVVQACLALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYPERVLNLVMQLNRTVCLD 745

Human   562 LPQ--LP-------------RELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMD 611
            .|:  :|             :.|..|.:..:|.::|..||..:.||..:...|:.|.|||.|..|
  Fly   746 FPEANVPWFQQNYIEAQISKKSLIPSESTTEVKQLLHQLLQNDKHFRCNHTTPYGYQIDFVIHFD 810

Human   612 TNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGS-SHPRGFLAMKMRHLNAMGFHVILVN-- 673
            .::|.: |...|:.|....|.:||:|.:...::|... :..||..::|||||..||:.|:.:|
  Fly   811 RDKNPI-PAPPVEATMLDRITKVAILLLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEH 874

Human   674 NWEMDKLEMEDA-VTFLK 690
            :|....:....| ..:||
  Fly   875 DWNSKYMASSTAKANYLK 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASTKD2	NP_001129665.1	FAST_1	457..527	CDD:310980	17/83 (20%)
		FAST_2	<572..618	CDD:312018	15/45 (33%)
		RAP	636..692	CDD:214932	17/59 (29%)
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	6/65 (9%)
		FAST_2	736..816	CDD:285557	20/79 (25%)
		RAP	834..894	CDD:214932	17/59 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010