Protein Alignment FASTKD2 and CG31643

DIOPT Version :10

• Sequence 1: NP_055744.2
• Gene: FASTKD2 / 22868
• HGNCID: 29160
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_723145.1
• Gene: CG31643 / 318867
• FlyBaseID: FBgn0051643
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 863
• Identity: 169/863 - (19%)
• Similarity: 295/863 - (34%)
• Gaps: 282/863 - (32%)

Human    45 CLGLCKPKIVHS---NWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALRIERL 106
            |.||....:|..   .|||   :|:..|::       :||...:..:....|....:..|.|:.|
  Fly    95 CDGLQSSHVVMGISLLWNI---YHDAEQAS-------KDAITDRVLLNVLPKLAPYVHQLEIDDL 149

Human   107 ----LYAKRLFFDSKQSLVPV----------DKSDDEL--------KKVNLNHEVSNEDVLTKET 149
                ||.:::...:.:::|..          .:.|||:        ..|.:|.|   .|..|...
  Fly   150 SRCYLYLRKMHIPNSEAVVEAVLTRSLQLIESQVDDEVIPLTSLSRLSVGINLE---RDFFTPLV 211

Human   150 KPN-------RISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLM 207
            ..|       .|:..:.:|:...||..|              |...:.|.:.|.   .||:.||
  Fly   212 CRNFIPHLEHHINWCRSAEQVRLLSTCL--------------FQLHFLIDEELF---TRFKLRL- 258

Human   208 FSHPAFNQLCEHMMREAKIMQY--KYLLFSLHAIVKLGIP----QNTILVQTLLRVTQERINECD 266
                      ..||:...:...  |.||..:|   .|.||    .:|.|::.::.|.:..|::.:
  Fly   259 ----------TEMMQSGVLSSETPKALLKVIH---MLNIPVWSQTHTQLIREVMLVLRPCIHQME 310

Human   267 EICL-SVLSTVLEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLE 330
            ...| |:..|.|...||...:..|:.....|:.::       .|...:...:....|  |:|...
  Fly   311 SADLKSICRTFLHHQEPAALIEPLKKALEKLLQEE-------GTADALFCAVPFATP--LQRDQY 366

Human   331 MKALREL----DRFSVLN-SQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLR-IMINILQSC 389
            :...:||    :.:...| |.|:|.||.|:....:...:.....|:..:..||.: :.:..|:.|
  Fly   367 LHQFKELLYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHLHLRFLRHC 431

Human   390 KDLQ---------YHNLDL-----------------------FKGLADYVAA---TFDIW-KFRK 418
            :...         |.:|:|                       |..||.:|.|   |...| ||..
  Fly   432 QRYMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKKFPN 496

Human   419 VLFILILFENLGFRP-VGLMDLFM------------------------------------KRIVE 446
            .|    |.:.|...| :|:.|.|:                                    :|.:.
  Fly   497 FL----LSKMLAMAPQLGIQDCFLLSRGMQIASELRFRQHLPALAGMQLSTMDSILIGCAERHLR 557

Human   447 DPES--LNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLMN 509
            |.|.  ||...:..|:.|   |:|..|.:|...:.:.:|.....:.:.::|..:.|..|:|...|
  Fly   558 DAEKDPLNASELSMIVRT---LSHRKKLKNTVVYNQALAQYKNLHCNDLNSRVVRDMAYNFNASN 619

Human   510 YFPLAPFNQLLQK--------------DIISELLTSD----------------------DMKNAY 538
            :|  .|  :||:.              |.:.::||..                      |.....
  Fly   620 FF--VP--ELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMPASVEALNHASEVLLRDFDQMS 680

Human   539 KLHTLDTCL-----------------------KLDDTVYL-------------------RDIALS 561
            .|..:..||                       :::|.:.:                   |.:.|.
  Fly   681 GLSVVQACLALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYPERVLNLVMQLNRTVCLD 745

Human   562 LPQ--LP-------------RELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMD 611
            .|:  :|             :.|..|.:..:|.::|..||..:.||..:...|:.|.|||.|..|
  Fly   746 FPEANVPWFQQNYIEAQISKKSLIPSESTTEVKQLLHQLLQNDKHFRCNHTTPYGYQIDFVIHFD 810

Human   612 TNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGS-SHPRGFLAMKMRHLNAMGFHVILVN-- 673
            .::|.: |...|:.|....|.:||:|.:...::|... :..||..::|||||..||:.|:.:|
  Fly   811 RDKNPI-PAPPVEATMLDRITKVAILLLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEH 874

Human   674 NWEMDKLEMEDA-VTFLK 690
            :|....:....| ..:||
  Fly   875 DWNSKYMASSTAKANYLK 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASTKD2	NP_055744.2	RESC6-like	181..407	CDD:480594	52/270 (19%)
		FAST_1	456..529	CDD:461999	17/86 (20%)
		FAST_2	<578..619	CDD:462448	14/40 (35%)
		RAP	636..692	CDD:214932	17/59 (29%)
CG31643	NP_723145.1	FAST_1	645..715	CDD:461999	6/69 (9%)
		FAST_2	735..817	CDD:462448	20/82 (24%)
		RAP	834..894	CDD:214932	17/59 (29%)