Protein Alignment CILK1 and cilk1

DIOPT Version :9

• Sequence 1: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Sequence 2: XP_002934912.3
• Gene: cilk1 / 100498050
• XenbaseID: XB-GENE-985841
• Length: 623
• Species: Xenopus tropicalis
• Alignment Length: 653
• Identity: 390/653 - (59%)
• Similarity: 471/653 - (72%)
• Gaps: 45/653 - (6%)

Human     1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKL 65
            ||||||::||||||||||:||||:|||||:||||||||||||:|||||||||||||||||||:||
 Frog     1 MNRYTTVKQLGDGTYGSVILGRSVESGELVAIKKMKRKFYSWDECMNLREVKSLKKLNHANVIKL 65

Human    66 KEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130
            |||||||:.|||:|||||||||||:|:||||||||.|||||||||||||:|||:|||||||||||
 Frog    66 KEVIRENNQLYFVFEYMKENLYQLMKDRNKLFPESIIRNIMYQILQGLAYIHKYGFFHRDLKPEN 130

Human   131 LLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYT 195
            |||||||||||||||||||.||:||||||||||||||||||||:|||:||||:|||||||||:||
 Frog   131 LLCMGPELVKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRATNYNSPIDIWAVGCIMAEIYT 195

Human   196 LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQL 260
            |||||||:||:|||||||||||||||.||.||:||:|||||||..|||:|||||||||.::.:|:
 Frog   196 LRPLFPGSSEVDTIFKICQVLGTPKKNDWFEGFQLASAMNFRWAHCVPSNLKTLIPNACADGIQV 260

Human   261 LRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQP 325
            :||||||||||||||||||||.|||||..|| |:..:.:..|.||...||. ....||||||.:|
 Frog   261 MRDMLQWDPKKRPTASQALRYSYFQVGQTLG-TSPRIHELSKQQKEPHEKQ-ISLQIKPVPPTRP 323

Human   326 PAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQE-DKPSPLLFPSLHNKHPQSVSSPD 389
            |  |..|:.||..|.|||   ...|:|...|.|:..|..|| ||......|:|..:.||
 Frog   324 P--PKHRLPSRAFQPSQP---YANPFKQSPSWTEPFSLSQEKDKVGQPHLPALSTRVPQ------ 377

Human   390 SPKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLC 454
              |..:..|..|||:..|:|||||.::::.|.||:|.|.|| |...|..|.::|..::|::|.:.
 Frog   378 --KAASDTESANGELNLKTRRRWGHVTKTIKGSDEWDDSDD-DVHFSNPRTEIKQNEKQNEDAVH 439

Human   455 RFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLR--SAAKQHYLKHSRYLPGISIRNGI----- 512
            .|:|::|||.::   .|::.....|:.::|:.|.|  ||||||||||||||||::|.|..
 Frog   440 SFKSIVDLKNAD---NGSAGSELNSFAQQDSATSRRASAAKQHYLKHSRYLPGLTINNSAGKSSS 501

Human   513 -----LSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIG 572
                 :|||..  ||..|....||:          |:.||..|....||....:|:|:||||:||
 Frog   502 SDSTNVSNPWP--IPLQPIKPLGLA----------SETNSRLSGQKGSSDPVSSYLPAFLKKDIG 554

Human   573 SAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRP-PAAQPVHGRTDWASKYA 636
            ...|:|.|||:.||:|.|.||:::....|.|.|.:..:.|..|..:| |...||||||||.|||.
 Frog   555 YIGQKVQLAPLTDPTPNYGSLRSVGSFLGPPSFRSPSKGTQRLTSKPAPPVFPVHGRTDWLSKYG 619

Human   637 SRR 639
            ..|
 Frog   620 GHR 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	241/279 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344		23/53 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639		21/50 (42%)
cilk1	XP_002934912.3	STKc_MAK_like	4..284	CDD:270824	241/279 (86%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	526	1.000	Domainoid score	I3315
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69218
Inparanoid	1	1.050	738	1.000	Inparanoid score	I5001
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41361
OrthoDB	1	1.010	-	-		D124197at7742
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		oto159631
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3024
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110