DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHSY1 and CG9220

DIOPT Version :9

Sequence 1:	XP_011519666.1	Gene:	CHSY1 / 22856	HGNCID:	17198	Length:	830	Species:	Homo sapiens
Sequence 2:	NP_001285280.1	Gene:	CG9220 / 32497	FlyBaseID:	FBgn0030662	Length:	832	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	338/862 - (39%)
Similarity:	484/862 - (56%)	Gaps:	133/862 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     9 WLSVLLGLVLGFVLASRLVLP--RASELKRAGPRRRASPEGCRSGQAAASQAGGARGDARGAQLW 71
            :..:.|||.:|.:|.:.|.|.  :...|:....:..|...|.|......:.
  Fly    16 FFGIALGLCIGTMLKNYLALEIVKRCSLRPTNLKTPADIIGLRDEDTIQNS-------------- 66

Human    72 PPGSDPDGGPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVQFFSSEGSDTSVPIPVVPL 136
                       .||.:|||||||:.:|:.||.|.|.||.|.:||::.||||||| .|..:|||.|
  Fly    67 -----------QRNLVFVGVMTAKSFLEGRARAVYDTWGKEVPGRMAFFSSEGS-YSDDLPVVGL 119

Human   137 RGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLENFLRSLNSSEPLFLGQTGL 201
            :.|||.|||||||||||.||::||:|::|||:|||||||::.|:||.||||::||:|.|:||.|.
  Fly   120 KNVDDRYPPQKKSFMMLYYMYEHYIDRFEWFIRADDDVYMEPDKLERFLRSIDSSKPQFIGQAGK 184

Human   202 GTTEEMGKLALEPGENFCMGGPGVIMSREVLRRMVPHIGKCLREMYTTHEDVEVGRCVRRFAGVQ 266
            |.:||.|.|:||..|||||||||||:|.|.|||:.|||..||:.:|:|||||||||||::|||:.
  Fly   185 GNSEEFGLLSLEFDENFCMGGPGVILSSETLRRVAPHIPSCLKNLYSTHEDVEVGRCVQKFAGIP 249

Human   267 CVWSYEASPVACLCQCLRHSLFLMILTVLRSASQMQQLFYENYEQNKKGYIRDLHNSKIHQAITL 331
            |.|:||...:      |||:                       ...:..|...|...:||.||||
  Fly   250 CTWNYEMQYI------LRHN-----------------------SSGRNAYTGKLKRKEIHNAITL 285

Human   332 HPNKNPPYQYRLHSYMLSRKISELRHRTIQLHREIVLMSKY------------------SNTEIH 378
            ||.|..|..||||||:...|..|:|..::.|||:|..|:||                  .:|:.|
  Fly   286 HPIKQAPLMYRLHSYVQGLKAEEMRQESLLLHRDIKRMAKYLEVPDESTYMLPSVSPESDSTKRH 350

Human   379 KEDLQ-LGIPPSFMRFQPRQREEILEWEFLTGKYLYSAVDGQPPRRGMDSAQREALDDIVMQVME 442
            .:|.. |||.|...:|.|...:::|:|.|: .:.||||....|.:: :|||.||.|:|.:.:|||
  Fly   351 FQDHNILGISPELNKFVPASTDDLLDWSFI-ARSLYSASSANPKQK-IDSAMREGLEDAITEVME 413

Human   443 MINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSK 507
            .||..::.|||:|:|:|:.|||.|::.::|.:.||||||:|||::|||||||||||.|:|:.|:.
  Fly   414 NINNYSRQRGRVIEFRELLYGYHRLDALHGQDMILDLLLIYKKYRGKKMTVPVRRHLYVQRAFTG 478

Human   508 IQFVEHEELDAQELAKRINQESGSLSFLSNSLKKLVP-FQLPGSKSEHKEPKDKKINILIPLSGR 571
            | ||:..:.|...:..   |:|...|...|.:.:|.. |.:|   |....|...||..::|::||
  Fly   479 I-FVKEVDEDFYNVTL---QQSLLGSLFQNGMARLSSHFTMP---SGLLSPTQDKIVFVLPIAGR 536

Human   572 FDMFVRFMGNFEKTCLIPNQNVKLVVLLFNSDSNPDK-AKQVELMRDYRIKYPKADMQILPVSGE 635
            ...|.||:..:|:.|:...|:..|:|::|.|   ||: ...::|:.|...::....:..:..|..
  Fly   537 LGTFERFLRTYERVCVRGEQHCDLLVVIFGS---PDELGDHLQLLHDLHARHVYQQVNWIQRSSA 598

Human   636 FSRALALEVG--SSQFNNESLLFFCDVDLVFTTEFLQRCRANTVLGQQIYFPIIFSQYDPK---- 694
            |||.:||:|.  ||....|.::.|.|||:||..|.|||.|.:|..|:|:|.||:||||||:
  Fly   599 FSRGVALDVAARSSYIRQEDIILFIDVDMVFEVETLQRVRMHTQRGKQVYLPIVFSQYDPQRRSG 663

Human   695 ----IVYSGKVPSDNHFAFTQKTGFWRNYGFGITCIYKGDLV--RVGGFDVSIQGWGLEDVDLFN 753
                ....|:.|     ....:.|::|.:||||..|||.|::  .:.|||..|.|||||||....
  Fly   664 DAGGSEDEGETP-----RIDDERGYFRQFGFGICAIYKSDILDEDINGFDKDITGWGLEDVKFLE 723

Human   754 KVVQAG--------------------------LKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCL 792
            |:|:.|                          |..||:.:..:||::|.:.||..||..||.|||
  Fly   724 KIVRVGTRQRGFLANTAELAMDYNEAAEQWRRLSVFRAPDPTLVHIYHDISCDVQLDAPQYNMCL 788

Human   793 GSKASTYGSTQQLAEMW 809
            |:||::.|||:.:.:::
  Fly   789 GTKANSLGSTRLMEQLF 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHSY1	XP_011519666.1	Galactosyl_T	87..>265	CDD:304462	114/177 (64%)
CHSY1	XP_011519666.1	CHGN	238..805	CDD:283361	229/625 (37%)
CG9220	NP_001285280.1	Galactosyl_T	71..>251	CDD:304462	115/180 (64%)
CG9220	NP_001285280.1	CHGN	221..799	CDD:283361	228/623 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147687
Domainoid	1	1.000	397	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_KOG3588
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8950
Inparanoid	1	1.050	602	1.000	Inparanoid score	I953
Isobase	1	0.950	-	0.938488	Normalized mean entropy	S4160
OMA	1	1.010	-	-		QHG49419
OrthoDB	1	1.010	-	-		D211685at33208
OrthoFinder	1	1.000	-	-		FOG0002300
OrthoInspector	1	1.000	-	-		otm41360
orthoMCL	1	0.900	-	-		OOG6_104399
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3461
SonicParanoid	1	1.000	-	-		X2344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750