DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NTNG1 and wb

DIOPT Version :9

Sequence 1:	NP_001106697.1	Gene:	NTNG1 / 22854	HGNCID:	23319	Length:	539	Species:	Homo sapiens
Sequence 2:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	138/482 - (28%)
Similarity:	205/482 - (42%)	Gaps:	95/482 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    71 TCG-DPPETFCAMGNPYMCNNECDASTPELAHPPELM--------------FDFEGRHPSTFWQS 120
            ||| :..|.:|.......| ..|:|.:.:.|....:.              |: ||     :|||
  Fly   171 TCGQNGAEEYCKQVGAKPC-GICNAHSSDRAKQRSIQSLISSGSGSGSGSGFE-EG-----WWQS 228

Human   121 ATWK-----EYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYA- 179
            .|.:     ||     |.|.|...:|.::....:.:..|.||...||||||| |..::|:||:.
  Fly   229 PTLQGGRQFEY-----VTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGL 287

Human   180 --TDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMAS 242
              .||...:::..::.|.:.|:.. ||||:.::|......:.::|..:           |:|..
  Fly   288 SDADCQRRWNLSGQNGKYVFQNDT-EIICSTQFSKPGPLENGVLHASL-----------LKNRP- 339

Human   243 LYGQLDTTKKLRDFFTVTDLRIRL--LRPAVG-----EIFVDELHLARY-FYAISDIKVRGRCKC 299
              |..|.:.:|..|.|...:||||  :.....     :..:|...|.:: ||::|.:||..|..|
  Fly   340 --GATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDC 402

Human   300 NLHATVC--VYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIG 362
            |.||...  ..|:..:.|.|:|||.|..|.:|...:|.||:..|....|
  Fly   403 NGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECEI---------------- 451

Human   363 NCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGS 427
             |:|:||:..|:|...|:..||.||.:||.|..||.|.:|::|...|.|.|.  |:.|.|||..|
  Fly   452 -CQCYGHAESCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCNPARS 513

Human   428 IHDRCNGSGFCECKTGTTGPKCDECLPGNSWHYG--CQPNVCDNELLHCQNGGTCHNNVRCLCPA 490
            .....:..|.|.|..|..|..|:||.||   :||  |:...|| |.....:.|:|..  .|.|..
  Fly   514 TGGCQSDGGSCNCLEGFQGKNCEECAPG---YYGDDCKRCECD-ERGSLGSTGSCSG--VCQCKL 572

Human   491 AYTGILCEK-------LRCEEAGSCGS 510
            ...|..|.:       |..|.|..|.|
  Fly   573 NVEGSTCSECAPGYFDLSAENAEGCTS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTNG1	NP_001106697.1	Laminin_N	71..295	CDD:395009	64/254 (25%)
		NGL discriminant loop I	80..91		2/10 (20%)
		NGL discriminant loop II	208..214		1/5 (20%)
		NGL discriminant loop III	273..275		0/1 (0%)
		EGF_Lam	296..342	CDD:238012	17/47 (36%)
		EGF_Lam	364..412	CDD:238012	20/47 (43%)
		EGF_Lam	420..467	CDD:214543	18/48 (38%)
wb	NP_723870.1	Laminin_N	164..396	CDD:278484	62/252 (25%)
		EGF_Lam	401..450	CDD:238012	17/48 (35%)
		TNFRSF	<407..507	CDD:304602	37/118 (31%)
		EGF_Lam	505..552	CDD:238012	18/49 (37%)
		Laminin_EGF	550..597	CDD:278482	12/49 (24%)
		Laminin_B	660..798	CDD:278481
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012
		CrfC	<1933..2267	CDD:223771
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10902
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810