DRSC/TRiP Functional Genomics Resources

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Protein Alignment NTNG1 and LanA

DIOPT Version :9

Sequence 1:NP_001106697.1 Gene:NTNG1 / 22854 HGNCID:23319 Length:539 Species:Homo sapiens
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:538 Identity:144/538 - (26%)
Similarity:216/538 - (40%) Gaps:136/538 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    60 YLKVKLDPP------------DITCG---DPPETFCAMGNPYMCNNE----------------CD 93
            |.:.:|.||            ..|||   |.||.:|.:..   .|.|                ||
  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVG---ANTEHDHIDYSVIQGQVCDYCD 80

Human    94 ASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPD 158
            .:.||..||||...|    ....:|||.......|..:||:|:::.:...:....:....|.||.
  Fly    81 PTVPERNHPPENAID----GTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPG 141

Human   159 QMILEKSLDYGRTWQPYQYYA---TDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKI 220
            ...||||.|||:||.|:|:::   .||...|..|  :.|.:::..  ::|||.||       |||
  Fly   142 LWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKD--TYKPITRDD--DVICTTEY-------SKI 195

Human   221 IHFE--------IKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRP--AVGEIF 275
            :..|        :.:|      |...|..:       :..|:::...|::||||||.  .:|.:.
  Fly   196 VPLENGEIPVMLLNER------PSSTNYFN-------STVLQEWTRATNVRIRLLRTKNLLGHLM 247

Human   276 ----VDELHLARYFYAISDIKVRGRCKCNLHATVCVYDNSK-----LTCECEHNTTGPDCGKCKK 331
                .|.....||||:|.||.:.|||.||.||..|...:.|     |.|.|:|:|.|..|.:|..
  Fly   248 SVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCP 312

Human   332 NYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTV-------------- 382
            .::.:.|...:     ......|.|       |.|.||||.|.|.:.:|..              
  Fly   313 GFEQKKWRQNT-----NARPFNCEP-------CNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGG 365

Human   383 ICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGP 447
            :|.:|:|||.|.:|..|:..|:|......::.:||..|.|:...|.......:|.|||:.....|
  Fly   366 VCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPP 430

Human   448 KCDECLPGNSWHYG------CQPNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEK------- 499
            .||.|..|   :||      |:.|:......||:    ..:..:|.|...:.|..|::       
  Fly   431 SCDSCAYG---YYGYPNCRECECNLNGTNGYHCE----AESGQQCPCKINFAGAYCKQCAEGYYG 488

Human   500 ------LRCEEAGSCGSD 511
                  ..|.:.||..:|
  Fly   489 FPECKACECNKIGSITND 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NTNG1NP_001106697.1 Laminin_N 71..295 CDD:395009 73/259 (28%)
NGL discriminant loop I 80..91 2/10 (20%)
NGL discriminant loop II 208..214 2/5 (40%)
NGL discriminant loop III 273..275 0/1 (0%)
EGF_Lam 296..342 CDD:238012 17/50 (34%)
EGF_Lam 364..412 CDD:238012 19/61 (31%)
EGF_Lam 420..467 CDD:214543 16/52 (31%)
LanANP_476617.1 LamNT 18..271 CDD:214532 77/282 (27%)
EGF_Lam 272..>314 CDD:238012 16/41 (39%)
EGF_Lam 332..389 CDD:238012 19/63 (30%)
EGF_Lam 402..443 CDD:238012 14/43 (33%)
EGF_Lam 448..491 CDD:238012 8/46 (17%)
Laminin_EGF 495..543 CDD:278482 4/12 (33%)
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:278482
Laminin_EGF 1514..1562 CDD:278482
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:278482
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2129..2385 CDD:283627
Tar 2278..2662 CDD:223910
Laminin_II 2566..2700 CDD:283628
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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