Protein Alignment AAK1 and aux

DIOPT Version :10

• Sequence 1: NP_001413674.1
• Gene: AAK1 / 22848
• HGNCID: 19679
• Length: 1132
• Species: Homo sapiens
• Sequence 2: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Alignment Length: 1228
• Identity: 278/1228 - (22%)
• Similarity: 432/1228 - (35%)
• Gaps: 318/1228 - (25%)

Human     4 FFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSN 67
            :|.|....|.:|.|:..:.||    .|.:.::|:|..:...::.:..|:||||:|.|::.: ...
  Fly    12 YFSSSEVNGAAGNGAPEALGG----RLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQT 72

Human    68 GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG 132
            |.:.||||:...:.........||.|.:.||||:|||.::.||....|:....:.|:|.:.|:||
  Fly    73 GTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGG 137

Human   133 QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGS 197
            .:|:..... ...|....||:||.....|||.||....||.|||:|:||.|:.:.....||||||
  Fly   138 SLVDCFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGS 201

Human   198 ATNKFQNPQTEGV----NAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 258
            |:.:..:|..|..    :.:||::...||..||:|||::.:|...|..|.|||||||:||.|||.
  Fly   202 ASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYR 266

Human   259 TLPFGE-SQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKL-------L 315
            ..|:.: .::.|.:.|:.:|.:.:| |....:||..|:.:|.:|.||..|......|       |
  Fly   267 KHPYEDGGKLRIINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSL 330

Human   316 KKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT---ETSIAPRQRPKAGQTQP 377
            |....:..:....:||:  .|:|:|..:...|:|   |:..||::   ..|:....|..||....
  Fly   331 KGPLDLHIMPIESLPAE--SPLKSSAYSEVYTEP---LSAAIPSSYNGHGSLLSSLRGGAGTLLK 390

Human   378 NPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTP 442
            |     |:...|     .|....|.:.:.|...:.....:......||.....|
  Fly   391 N-----IKDTST-----KVMQTMQQSLARNDLDISHITSRILVMPCPSDGFEST----------- 434

Human   443 QQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT 507
            .:|.:.:...|..:::..||........|:.:.:.|||.:...||:.|...||.....|.:
  Fly   435 YKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGL---- 495

Human   508 QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQ--QQQQQQQLATALHQQQLMTQQAALQQKPTMA 570
                   |.|.:.       |.||.....:..  .|.......||......:...|.|.::|
  Fly   496 -------FTVSAD-------MYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREP--- 543

Human   571 AGQQPQPQPAAAPQPAPAQEPAQIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRR 635
                              ::..|:.|..|.                ..:|.|
  Fly   544 ------------------EDAVQVFAVKRH----------------TINLRP------------- 561

Human   636 ILSDVTHSAVFG--------VPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSE 692
              |:..:...||        :|..|:|.|:           |.|....|..:.......:|
  Fly   562 --SEFRYLYYFGDILRPTPLLPHYKNTTLV-----------SLSCQPVPRMTKARDGCRIY---- 609

Human   693 GSTWNPFDDDNFSKLTAEELLNKDFAKLGEGK--HPEKLGGSAESLI------PGFQSTQGDAFA 749
               ...:.:.|....|.::.......:.|.||  .|..|....:..:      .|....||....
  Fly   610 ---MEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRPQGLKIC 671

Human   750 TTSFSAG-----------TDLQRESNPCPVITVEHFKESLGVKGLPLYPDPSRVPGTKTQNNLES 803
            ...|:.|           |:...:..|.|......|..||.:........||..|
  Fly   672 QFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKP---------- 726

Human   804 DYLARDGPSSNSSFHSSEEEGTDLE-GDMLDCSGSRPLLMESEEEDESCRPPPGKLGG---AVPF 864
            .::......|.::..||     ||| .:|||...::|....|        ||||....   :.|.
  Fly   727 PWMPAKPKRSPAALFSS-----DLEYAEMLDNFVTKPSTRSS--------PPPGARKSDRVSSPL 778

Human   865 APPEVS----------PEQAKTVQGGRKNQFQAFTQPATDGLSE--------------------- 898
            ..|:|:          ||.:..:.....|| |....||.|.|:.
  Fly   779 VLPDVTETAHELPSPMPEPSPPIDLLNLNQ-QPSDVPAADPLTSAKPSTDASFDLLGAFGDDDST 842

Human   899 -------PDVFAIAPFR--SSRVPNDDMDIFSKAPFVSKSSMAPSQ-PEESDVFLRAPFTKKKSM 953
                   ||:....|.:  ..::.||..|||.........||.||. |         ||.
  Fly   843 GIGSAPIPDILPPPPLQQPQPKINNDPFDIFGSVDQGGVPSMKPSGFP---------PFV----- 893

Human   954 EELTVIQCTSQELPAQTGLLSQTGDVPLPAGRERAVYTSVQAQYSTAGFVQQSNLLSHSVQAADH 1018
                      ..||......:.|.: |.|....||                          :||.
  Fly   894 ----------GSLPTFVAQPAATTN-PSPTHPARA--------------------------SADP 921

Human  1019 LDSISPRGSCLESGGHSNDRNKGPQLQKEAVSG--PMAGKPFRPQSLSKYSRHYSPEDEPSPEAQ 1081
            ..:|:.    |.:|.:.|       ..:..:||  |:...| :|...|      ||..:|||.:|
  Fly   922 FANIAD----LATGLNLN-------FNRSTLSGKSPVNTSP-QPTQFS------SPTHKPSPSSQ 968

Human  1082 PIAAYKIVSQTNKQSIAGSVSITSLSSRTTELPAADPFALAP------FPS-KSGKKP 1132
            |.|.:.....| .|::..:.||     ||...|.|.|....|      |.| |:.::|
  Fly   969 PQATFMHTPPT-PQTLPSTSSI-----RTPTQPQAVPAQSRPDYSRLHFDSQKAAQQP 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AAK1	NP_001413674.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..493		34/168 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..702		4/36 (11%)
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	98/278 (35%)
		PTP_auxilin-like	404..573	CDD:350361	38/249 (15%)
		PTEN_C2	581..711	CDD:463081	24/147 (16%)
		PHA03247	<698..1037	CDD:223021	91/422 (22%)
		Herpes_BLLF1	<882..>999	CDD:282904	42/191 (22%)
		DnaJ	<1110..1150	CDD:99751