Protein Alignment AAK1 and aux

DIOPT Version :9

• Sequence 1: NP_055726.4
• Gene: AAK1 / 22848
• HGNCID: 19679
• Length: 961
• Species: Homo sapiens
• Sequence 2: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Alignment Length: 1049
• Identity: 240/1049 - (22%)
• Similarity: 388/1049 - (36%)
• Gaps: 224/1049 - (21%)

Human     4 FFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSN 67
            :|.|....|.:|.|:..:.||    .|.:.::|:|..:...::.:..|:||||:|.|::.: ...
  Fly    12 YFSSSEVNGAAGNGAPEALGG----RLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQT 72

Human    68 GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG 132
            |.:.||||:...:.........||.|.:.||||:|||.::.||....|:....:.|:|.:.|:||
  Fly    73 GTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGG 137

Human   133 QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGS 197
            .:|:..... ...|....||:||.....|||.||....||.|||:|:||.|:.:.....||||||
  Fly   138 SLVDCFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGS 201

Human   198 ATNKFQNPQTEGV----NAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 258
            |:.:..:|..|..    :.:||::...||..||:|||::.:|...|..|.|||||||:||.|||.
  Fly   202 ASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYR 266

Human   259 TLPFGE-SQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKL-------L 315
            ..|:.: .::.|.:.|:.:|.:.:| |....:||..|:.:|.:|.||..|......|       |
  Fly   267 KHPYEDGGKLRIINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSL 330

Human   316 KKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT---ETSIAPRQRPKAGQTQP 377
            |....:..:....:||:  .|:|:|..:...|:|   |:..||::   ..|:....|..||....
  Fly   331 KGPLDLHIMPIESLPAE--SPLKSSAYSEVYTEP---LSAAIPSSYNGHGSLLSSLRGGAGTLLK 390

Human   378 NPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTP 442
            |     |:...|     .|....|.:.:.|...:.....:......||.....|
  Fly   391 N-----IKDTST-----KVMQTMQQSLARNDLDISHITSRILVMPCPSDGFEST----------- 434

Human   443 QQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT 507
            .:|.:.:...|..:::..||........|:.:.:.|||.:...||:.|...||.....|.:
  Fly   435 YKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGL---- 495

Human   508 QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQ--QQQQQQQLATALHQQQLMTQQAALQQKPTMA 570
                   |.|.:.       |.||.....:..  .|.......||......:...|.|.::|
  Fly   496 -------FTVSAD-------MYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREP--- 543

Human   571 AGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRI 635
                               |.|:|....::..:...|
  Fly   544 -------------------EDAVQVFAVKRHTINLRP---------------------------- 561

Human   636 LSDVTHSAVFG--------VPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEG 692
             |:..:...||        :|..|:|.|:           |.|....|..:.......:|
  Fly   562 -SEFRYLYYFGDILRPTPLLPHYKNTTLV-----------SLSCQPVPRMTKARDGCRIY----- 609

Human   693 STWNPFDDDNFSKLTAEELLNKDFAKLGEGK--HPEKLGGSAESLI------PGFQSTQGDAFAT 749
              ...:.:.|....|.::.......:.|.||  .|..|....:..:      .|....||.....
  Fly   610 --MEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRPQGLKICQ 672

Human   750 TSFSAGTAEKRK-----GGQTVDSGLP-------------LLSVSD---------PFIPLQVPDA 787
            ..|:.|...:.:     ..|.:|. ||             .|:|:|         |::|.:...:
  Fly   673 FQFNTGFIPEPETLITFTNQDLDD-LPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRS 736

Human   788 PEKL----IEGLKSPDTSLLLPDLLPMTDPFGSTSDAV---IEKADVA-----VESLIPGLEPPV 840
            |..|    :|..:..|..:..|.......|....||.|   :...||.     :.|.:|...||:
  Fly   737 PAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARKSDRVSSPLVLPDVTETAHELPSPMPEPSPPI 801

Human   841 --------PQRLPSQTESVTSNR--TDS------LTGEDSLLDCSLLSNPTTDLLEEFAPTAISA 889
                    |..:|: .:.:||.:  ||:      ..|:|.  ...:.|.|..|:|   .|..:..
  Fly   802 DLLNLNQQPSDVPA-ADPLTSAKPSTDASFDLLGAFGDDD--STGIGSAPIPDIL---PPPPLQQ 860

Human   890 PVHKAAEDSNLISGFDVPEGSDKVAEDEFDP----IPVLI-----TKNPQGGHSRNSSGSSESSL 945
            |..|...|...|.|.....|...:....|.|    :|..:     |.||...|...:|....:::
  Fly   861 PQPKINNDPFDIFGSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANI 925

Human   946 PNLARSLLL 954
            .:||..|.|
  Fly   926 ADLATGLNL 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AAK1	NP_055726.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		6/20 (30%)
		STKc_NAK_like	42..316	CDD:270939	98/286 (34%)
		PHA03378	<296..461	CDD:223065	33/174 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..493		34/168 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..632		6/69 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..701		4/36 (11%)
		Clathrin-binding domain (CBD). /evidence=ECO:0000269|PubMed:17494869	823..960		37/162 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..860		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	921..945		6/28 (21%)
aux	NP_649438.1	PKc_like	49..326	CDD:304357	98/278 (35%)
		S_TKc	51..317	CDD:214567	97/267 (36%)
		PTEN_C2	581..711	CDD:287393	24/148 (16%)
		DnaJ	<1110..1150	CDD:197617

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D826336at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820