DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RHOBTB3 and Rac1

DIOPT Version :9

Sequence 1:	NP_055714.3	Gene:	RHOBTB3 / 22836	HGNCID:	18757	Length:	611	Species:	Homo sapiens
Sequence 2:	NP_001261247.1	Gene:	Rac1 / 38146	FlyBaseID:	FBgn0010333	Length:	192	Species:	Drosophila melanogaster

Alignment Length:	199	Identity:	46/199 - (23%)
Similarity:	80/199 - (40%)	Gaps:	43/199 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    34 LVSGDES---SLLLNAASTVARP------VFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNL 89
            :|.||.:   :.||.:.:|.|.|      ||..|.|:...:.|.:  :..:||....:.|.....
  Fly     7 VVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPI--NLGLWDTAGQEDYDRLRP 69

Human    90 IG--GADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGT--------------RQN 138
            :.  ..|:.:|.:::.:..||..|:..:.|.::....|.|:|:  |||              |..
  Fly    70 LSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIIL--VGTKLDLRDDKNTIEKLRDK 132

Human   139 EELPCTCPLCTSDRGSCVSTTEGIQLAKELGAT-YLELHSLDDFYIGKYFGGVLEYFMIQALNQK 202
            :..|.|.|             :|:.:|||:||. |||..:|....:...|...:...:...|..|
  Fly   133 KLAPITYP-------------QGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVLCPVLQPK 184

Human   203 TSEK 206
            :..|
  Fly   185 SKRK 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RHOBTB3	NP_055714.3	Rho-like	1..175		40/166 (24%)
		P-loop_NTPase	34..174	CDD:304359	39/165 (24%)
		BTB	413..515	CDD:279045
		Interaction with Rab9	420..611
		BTB	421..518	CDD:197585
Rac1	NP_001261247.1	Rac1_like	3..176	CDD:206663	43/185 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24072
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000