Protein Alignment NLGN4Y and Nlg3

DIOPT Version :9

• Sequence 1: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 290/916 - (31%)
• Similarity: 424/916 - (46%)
• Gaps: 216/916 - (23%)

Human    39 IDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNA 103
            :.:|....::||..|.|.|:...|....|.|||.|.|:||||||.|..||.||.|.:.|:|::.|
  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKA 213

Human   104 TQFSAVCPQHLDERFLLH------DMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPME------ 156
            .:||.||||.|.:   :|      :.:|......|..|:.|:|:|:|||||||||||::
  Fly   214 DRFSPVCPQRLPD---IHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDS 275

Human   157 DGTNIKRNADDITSNDHGEDKDIHEQN-----------SKKPVMVYIHGGSYMEGTGNMIDGSIL 210
            .|::...:|...:|...|........:           :|.||:|::||.||...:||..|||:|
  Fly   276 SGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVL 340

Human   211 ASYGNVIVITINYRLGILGFLSTG-DQAAK--GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFG 272
            ||||.::|:|||||||:||||:.. |:.:|  .||||:|.|.||.|::||:.||||||..:|:.|
  Fly   341 ASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAG 405

Human   273 SGAGASCVSLLTLS-HYSEG-LFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGC-NMLDTTDM 334
            .|.||:||..|..| ...|| ||.:||:.||:.|:.|::...||||..|:|..|.| :.|....:
  Fly   406 HGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHL 470

Human   335 VECLKNKNYKELIQQTITPATYHIAFGPVIDGDVI---------PDDPQ---------------- 374
            ::||:.|...:|:...|.|..:..||||.|||.||         |..|.
  Fly   471 MKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG 535

Human   375 --------------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVDGIVDNEDGVTPNDF 415
                                :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:..:..
  Fly   536 GEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIEADRR 598

Human   416 DFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADKENP-----ETRRKTLVALFTDHQWVAP 472
            ...:..:|.|.|.:     .|.|   ||...||||   |.|     ..|.:||.|| :|.|.|||
  Fly   599 SRILKAYVRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAP 654

Human   473 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDV 537
            |..|.|||:.....:|.|.|.:..:....|......||:::||:||.|::|....|:.|::|.::
  Fly   655 AAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEI 719

Human   538 MLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWSKYNPKDQLYLHIGLKPRVR 599
            .||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||:::
  Fly   720 SLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLK 780

Human   600 DHYRATKVAFWLELVPHLHN--------------------------------------------- 619
            :||||.:::|||.|:|.||.
  Fly   781 NHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAA 845

Human   620 -------LNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTG 677
                   .|::|..::.::    |..:....|||....||:|......            .|..|
  Fly   846 MANFTIFTNQVFSLLNLSS----PSSSLQRNGTRYGGGKIYPDDMMDG------------DHAGG 894

Human   678 PEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRHPSPQ-------- 734
            ....:...:....|||.||||||:|.|||.||:|.||.:||::||.|..   .|.||
  Fly   895 AASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLS---EPRPQTKLKRQEN 956

Human   735 ----RNTTNDITHIQNEEIMSLQMKQ-----LEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790
                .|...|:      |.:::..|.     |.|.|   ::|.|.    ..||::.        |
  Fly   957 GQMPNNICGDL------ETLTIHAKSDPATILSHHH---AMQHHQ----LPPPEFA--------D 1000

Human   791 IPFMTP 796
            ||...|
  Fly  1001 IPHRAP 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	230/652 (35%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	231/657 (35%)
		Aes	<313..>410	CDD:223730	52/96 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.930