DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NLGN4Y and Gli

DIOPT Version :9

Sequence 1:	NP_001352513.1	Gene:	NLGN4Y / 22829	HGNCID:	15529	Length:	836	Species:	Homo sapiens
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	893	Identity:	245/893 - (27%)
Similarity:	372/893 - (41%)	Gaps:	209/893 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    48 VNTNYGKIQGLR-----TPLP-----------SEILGPVEQYLGVPYASPPTGERRFQPPESPSS 96
            |.||||::||.:     .|.|           ..::|....:||:|||.|||.|.||:||.....
  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201

Human    97 WTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNI 161
            |. :..|..|...|||            |:.:|.:...:|    |.:|||||||:|.| :.|..:
  Fly   202 WQ-LLQAVDFGPACPQ------------PVRYTGATKGIM----DMDEDCLYLNVYSP-KTGAGV 248

Human   162 KRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 226
            .:                     |.|||||||||.::.|..|:..|.||||:.:|:|:|:|||||
  Fly   249 AQ---------------------KYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLG 292

Human   227 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEG 291
            .||||||||:.:.||||:|||..||||:.:|:..|.||...:|:||.|||.:...||.::..:..
  Fly   293 ALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRN 357

Human   292 LFQKAIIQSGTALSSWAV---NYQPAKYTRILADKVGCNMLDTTDMVECLK-NKNYKELIQQTIT 352
            :.::.|.|||:||:.||:   .|:....:|:|...:||::..:..:|.||: .:::.||.....:
  Fly   358 IVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFS 422

Human   353 PATYHIAFGPVIDGD-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGLK 398
            |......:|||:|.: .:|.|                 |:.|:..|:| .|...|.||...|...
  Fly   423 PQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAF 487

Human   399 FVDGIVDNE--------DGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPET 455
            ||   ..||        ||   ..||..:...|.. |.|....:.:.|.||::||.|.|..|...
  Fly   488 FV---AQNESLSPYYELDG---RFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTI 545

Human   456 RRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIP 520
            .|...:.:.:|..:.||......|..:...|.|.|......::...|.|....|..|..::.|.|
  Fly   546 IRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAP 610

Human   521 MIGPTELFSCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVA 578
            .: .||.|...       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.
  Fly   611 FM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIR 671

Human   579 W----SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMT 639
            :    :.||....|            :||.|:.|||.             ||:.|...|..|
  Fly   672 YLNINTTYNSSILL------------NYRQTECAFWT-------------QYLPTVIGVLVP--- 708

Human   640 SFPYGTRRSPAKIWPTTKRP------AITPA---------------NNPKHSKDPHKTGPEDTTV 683
            ::|..|     :.|...|.|      :::.|               .|.|...|  :...||..:
  Fly   709 TYPPTT-----EYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSD--RFYDEDVFI 766

Human   684 L---IETKRDYSTELSVTIAVGASLLFLNILAFAA---LYYKKDKRRHET-----H------RHP 731
            .   :|.::|       |..|..:.:..|..|..:   :|..:|....:|     |      |.|
  Fly   767 NGEGLEPEQD-------TRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSP 824

Human   732 SPQRNTTNDITHIQNEEIMSLQ------MKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790
            |....|....:....:..:||:      :||.|......|.|...|.::..||         .::
  Fly   825 SSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPP---------VEE 880

Human   791 IPFMTPNTITMIPNTLMGMQP---LHTFKTFSGGQNSTN-LPHGHSTT 834
            ...:.|  ::..|.|.:..:|   :.|..:.||...||. :|...|||
  Fly   881 KRLLQP--LSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTT 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	190/619 (31%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	190/619 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020