DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCAF8 and CG4266

DIOPT Version :9

Sequence 1:	NP_001273117.1	Gene:	SCAF8 / 22828	HGNCID:	20959	Length:	1349	Species:	Homo sapiens
Sequence 2:	NP_001097394.1	Gene:	CG4266 / 37411	FlyBaseID:	FBgn0034598	Length:	1306	Species:	Drosophila melanogaster

Alignment Length:	1470	Identity:	430/1470 - (29%)
Similarity:	594/1470 - (40%)	Gaps:	448/1470 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    79 MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYV 143
            ||.|..||:||..|.|.:||||||||..|||:|::|||.||||||||||||.|||||||||||||
  Fly     1 METVVAFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYV 65

Human   144 IDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQP 208
            |||||||||||:|.:||:|||||..|:..||.||:||..:|||:|:|||||||||||||||:|||
  Fly    66 IDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQP 130

Human   209 LLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQIL 273
            :.|:|                     .|..|:....|.....|.....|....::....::|.|.
  Fly   131 IFDLA---------------------DPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADIS 174

Human   274 QSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLEQGVSFN 338
            ..|.|..                       .:|:.:.:.:.........|    :..|..|
  Fly   175 SGPNGLN-----------------------SSGMEISMNSSGGDDKMGGA----MPDLSLG---- 208

Human   339 KKLMDRFDFGEDS---EHSEE--PKKEIPASQLSHVSES---------VNNSIFHQIAEQLQQQ- 388
               .::|..|..|   .:||:  .|::...|..|..|:|         .::.|.:|:.|.::::
  Fly   209 ---HEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQVREIIEEED 270

Human   389 -----------------------------------NLEHLRQQLLEQQQPQKATPQ-DSQEGTFG 417
                                               |..::.:||...|..|...|| ::|:..:.
  Fly   271 EGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLKPQEENQKHRYQ 335

Human   418 SEHSASPSQGSSQQHF---------LEP----EVNLDDSIDIQQQDMDIDEGQ-------DGVEE 462
            .|        :.||||         :.|    .:|::||:|:.:....|.|.|       ||.:.
  Fly   336 DE--------ALQQHFQNVMKGNAGMPPGMGMGMNMNDSMDLNKDVEFISEQQTIEVINLDGGDS 392

Human   463 EVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSR----ERKRKS--- 520
            .....:..:.   .|||.:||||:||||.|.:...:|:.:|:...|||||||    .|:|.|
  Fly   393 RSPTPDRDRY---KRSRRNSRSRTRSPRGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGSRDR 454

Human   521 ---SRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIE 582
               .||...:.|.||.|:||:|||||.|:.:.|||||||||||.:.|...|::|::.|.|:|.|.
  Fly   455 DRMDRSNRDKERDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIV 519

Human   583 SINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKT-EYKQFWDVDLGV 646
            ||:.|.|||||::.|..||||.:|:|.|.  ::|:..:.|.|:||..||||: |:|.:||::|||
  Fly   520 SIDQIVPRGCAFIVMNRRQDAHKAMQALK--NHKLQGRAITISWAAGKGVKSKEWKDYWDLELGV 582

Human   647 TYIPWEKVKVD-DLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPTPVEKETVVTTQAE 710
            |||||.|:..| |.:...||||.|::|:           |::...:..|:.. ..||....:.||
  Fly   583 TYIPWSKLSSDTDFDALEEGGMFDEDTM-----------PIQMKQKINQAKN-AAKEHKGASIAE 635

Human   711 VFPPPVAMLQIPVAPAVPTVSLVPP--AFPVSMPVPPP--GFSPIPPPPFLRASFNPSQPPPGF- 770
                         |...|:|.:.||  .|.:....|||  ...|:.|||      .|..||||.
  Fly   636 -------------AAGAPSVGVPPPNLIFGIDTTQPPPVGPVGPVGPPP------GPGAPPPGLM 681

Human   771 --------MPPP----VPPPVVPPPT-IPP--VVPTSLVQPSLSMTPETVKDVGFGSLVIPGGSV 820
                    |.||    :|||::.||| :||  ::||:.:.|.: |.|.|:...||     ||  :
  Fly   682 GMVRGQFPMAPPMGINMPPPIMMPPTNMPPPMMMPTTNMPPPM-MMPPTMMPPGF-----PG--I 738

Human   821 ASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISSGENTRSVIPNDISSNAAILGGQPPNVT 885
            .......|||.|..|..|                         ..:|..|.|     |||    .
  Fly   739 GGPPHPMALPPGAPFPPP-------------------------GAVPPPIPS-----GGQ----I 769

Human   886 SNSGILGVQRPNVSSNSEILGVRPSNVSSSSGIIAAQPPNILNNSGILGIQPPSVSN-------- 942
            ||||       |||.:...:.:   ::..:..:...|..|...:...:.:.|.:::|
  Fly   770 SNSG-------NVSDDQMDIEM---DLEDAPPLPPQQQANFNPSPSNVDLSPAAMANEMFQQRDR 824

Human   943 ---------SSGLLGVLPPNIPNNSGLVG-------VQPPNVPNTPGLLGTQPPAGPQNLPPLSI 991
                     |.|         |.||...|       .:.....|..|  |..|.:|   |.|.:.
  Fly   825 ERDRDNRDRSRG---------PGNSRWGGRDDVVEAAERWRAENGGG--GGGPGSG---LGPNAA 875

Human   992 PNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDSALHPPPRGPFPPGDIFSQ 1056
            .|:....:.:                      .|.:.|:|.|..:|......|.||...|
  Fly   876 FNEARARLNL----------------------NPIEHGMPRPDFMDFDNRGGPGGPRGMG----- 913

Human  1057 PERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPPIETRESISR---------PPPVD 1112
                                   |.||.|....|. |: |||.......::         |||..
  Fly   914 -----------------------PRGNHNGGGPGG-DF-FPPNMNHNRFNQPTSLMQMRIPPPAS 953

Human  1113 VRDVVGRPIDPREGPGRPPLDGRDHFGRP---------PVDIRENLVRPGIDHLGRRDHFG-FNP 1167
            ....:|.|.. ..|.|..|:..|:..|.|         |.........||    ||:...| |||
  Fly   954 FNQRMGGPAG-NGGNGVGPMFMRNQGGGPGGAGPSGGGPGGAGTGGGGPG----GRQQGPGFFNP 1013

Human  1168 EKPW--GHRGDFDEREHRVLPVYGGPKGLHEERGRFR----SGNYRFDPRSGP----WNRGFGQE 1222
            ..|:  ..||...:....|..|.||..|....|||:.    .|...|..|.||    .||..|:.
  Fly  1014 RNPFNDNQRGRGGQSGGGVRGVGGGGGGGPGGRGRWSDDEDEGGNNFKRRGGPGGPGGNRFRGER 1078

Human  1223 VHRDFDDRR---RPWERQRDRDDRDFDFCREMNGNRLG------RDRIQ---------------- 1262
            .....||||   ....|...|:||:    |...|||.|      |..|.
  Fly  1079 GGEMMDDRRGNNSRGGRGGPREDRE----RPGFGNRRGSRDDSNRHSISSTDEGNKAASETEPKP 1139

Human  1263 ----------NTWVPPPHARV----------FDYFEGATSQRKGDNVPQVNGENTERHAQPPPIP 1307
                      ||..|....||          .||.....:|:.        ||...:.|..||
  Fly  1140 KNVETELGSTNTGAPAAATRVDTEEDWDQELQDYEARMEAQKP--------GERASQSANSPP-- 1194

Human  1308 VQNDPELYEKLTSSNEINKEKSDTVADIESEPVVESTETE 1347
                   .|||.:.|| |..|.   ||:..:|:|..::||
  Fly  1195 -------QEKLPAENE-NFAKP---ADVTGDPLVAKSQTE 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAF8	NP_001273117.1	CID_SCAF8	83..213	CDD:340801	95/129 (74%)
		RRM_SCAF8	553..631	CDD:240908	36/77 (47%)
		PHA03247	<796..1159	CDD:223021	77/404 (19%)
CG4266	NP_001097394.1	CID	7..125	CDD:239621	88/117 (75%)
		RRM	<488..>593	CDD:223796	55/106 (52%)
		RRM_SCAF4_SCAF8	490..566	CDD:240673	36/77 (47%)
		DUF2413	1147..>1254	CDD:287302	26/98 (27%)
		Herpes_DNAp_acc	<1206..1304	CDD:282746	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149183
Domainoid	1	1.000	141	1.000	Domainoid score	I4726
eggNOG	1	0.900	-	-		E1_KOG0132
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002970
OrthoInspector	1	1.000	-	-		otm40643
orthoMCL	1	0.900	-	-		OOG6_105962
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1302
SonicParanoid	1	1.000	-	-		X1964
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.770