Protein Alignment PUF60 and NOP4

DIOPT Version :9

• Sequence 1: NP_001349824.1
• Gene: PUF60 / 22827
• HGNCID: 17042
• Length: 596
• Species: Homo sapiens
• Sequence 2: NP_015282.1
• Gene: NOP4 / 856063
• SGDID: S000005964
• Length: 685
• Species: Saccharomyces cerevisiae
• Alignment Length: 615
• Identity: 118/615 - (19%)
• Similarity: 202/615 - (32%)
• Gaps: 212/615 - (34%)

Human    99 EQQEALQKAKKYAMEQSI--------------KSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLS 149
            :.:|||.||:|......|              .|.:|:::.....:::|...........|:. |
Yeast    78 DTKEALAKARKTKFNGHILRVDIAKRRDRSKKTSEVVEKSTPESSEKITGQNNEDEDDADGED-S 141

Human   150 PLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPI--KSIDMSWDSVTMKHKGFAFV 212
            .|:.......|.:...||..|          .:::.|..:|.:  .:|....|.   |..|||||
Yeast   142 MLKGKPKLIIRNMPWSCRDPV----------KLKKIFGRYGTVVEATIPRKRDG---KLCGFAFV 193

Human   213 EYEVPEAAQLALEQMNSVMLGGRNIKV------GRPSNIGQAQPII------------------- 252
            ..:.....::|||....:.:.||.:.|      .|..:..:|||.:
Yeast   194 TMKKISNCRIALENTKDLKIDGRKVAVDFAVQKNRWEDYKKAQPEMNDKDDNESGNEDAEENHDD 258

Human   253 --DQLAEEARAFNR-------------------IYVASVHQDLSDDDIKSVFEAFGKIKSCTLAR 296
              |:..||.|..::                   ::|.:|..|.:::.:...|..||.:|......
Yeast   259 EEDENEEEDRQVDQASKNKESKRKAQNKREDFSVFVRNVPYDATEESLAPHFSKFGSVKYALPVI 323

Human   297 DPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAV 361
            |.:||..||..|:.::...:..:.:.  |....|...|.:|..|.|
Yeast   324 DKSTGLAKGTAFVAFKDQYTYNECIK--NAPAAGSTSLLIGDDVMP------------------- 367

Human   362 AAAAATAKITAQEAVAGAAVLGTLGTPGLVSPALTLAQPLGTLPQ--AVMAAQAPGVITGVTPAR 424
                        |.|....||..  ||.||      .:..|.:.:  |....:|.|...|....|
Yeast   368 ------------EYVYEGRVLSI--TPTLV------REDAGRMAEKNAAKRKEALGKAPGEKDRR 412

Human   425 PPIPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVM 489
                                 .|.||      .|..:...|:..::|:..: |.|...|.:..|.
Yeast   413 ---------------------NLYLL------NEGRVVEGSKMADLLTNTD-MEIREKSYKLRVE 449

Human   490 QKLLRKQES-----TVMVLRNMVDPKDIDD------------DLEGEV----------------T 521
            |  |:|..|     |.:.:||:  |:.::|            :...||                |
Yeast   450 Q--LKKNPSLHLSMTRLAIRNL--PRAMNDKALKALARKAVVEFATEVKNKERHPLSKEEIIRST 510

Human   522 EECGKFGAVNRVIIYQ---EKQGEEEDAEIIVKI------------FVEFSIASETHKAIQALNG 571
            :|..||...:.:...:   :|.|..:.|::|:::            ||||    ..||  .||.|
Yeast   511 KEKYKFMGPDEIEAQKKKDKKSGVVKQAKVIMEVKGSTAGRSRGYGFVEF----RDHK--NALMG 569

Human   572 -RWFAGRKVVAEVY------DQERFDNSDL 594
             ||.....|.::..      |:::..::||
Yeast   570 LRWLNCHAVTSDEILEGLNDDEKKQVDNDL 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PUF60	NP_001349824.1	half-pint	44..596	CDD:130706	118/615 (19%)
NOP4	NP_015282.1	RRM1_Nop4p	26..104	CDD:410075	7/25 (28%)
		RRM2_Nop4p	147..229	CDD:410076	20/94 (21%)
		RRM3_Nop4p	289..387	CDD:410077	27/138 (20%)
		RRM4_Nop4p	458..620	CDD:410078	30/150 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910