Protein Alignment DNAJC8 and CG10375

DIOPT Version :10

• Sequence 1: NP_055095.2
• Gene: DNAJC8 / 22826
• HGNCID: 15470
• Length: 253
• Species: Homo sapiens
• Sequence 2: NP_651185.1
• Gene: CG10375 / 42812
• FlyBaseID: FBgn0039116
• Length: 254
• Species: Drosophila melanogaster
• Alignment Length: 244
• Identity: 128/244 - (52%)
• Similarity: 178/244 - (72%)
• Gaps: 5/244 - (2%)

Human    14 GSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFR 78
            |::.:.|..||:|||:|||||||||...||:||.||||:||||||||||||:|||...:||||:|
  Fly    11 GTSHDNFEEFYTEVKEIEKRDSVLTPSQQIDRLLRPGSTYFNLNPFEVLQIEPEVELADIKKRYR 75

Human    79 QLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKK 143
            .||||||||||.|:.:|||.||:.|.:::|:|.::..:||.|:|.:..|...:..:.|::|:|||
  Fly    76 TLSILVHPDKNPDNQERAQMAFDIVSRSWKILENELTRKRCLEVYEEAKGRTDQMIAEKRKKLKK 140

Human   144 EGKPT-IVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKRERE 207
            ||:|| .:.||||..:|.|:|...|||||::|.:|::.:.::..||||:||.|||.:|:.|.:||
  Fly   141 EGRPTEPIPEDDPTKYKHAIYVMVMKLFADMERRRQKLDQRDQEERKRKRETEIEEEERIKADRE 205

Human   208 WQKNFEESRDGRVDSWRNFQA----NTKGKKEKKNRTFLRPPKVKMEQR 252
            ||:||||||..||:||.:||:    :.|.||:|.....:.|||.|.|.|
  Fly   206 WQQNFEESRQSRVNSWHDFQSGAGKSKKAKKQKHMTGMMVPPKFKPESR 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAJC8	NP_055095.2	DnaJ	57..184	CDD:440252	63/127 (50%)
		DnaJ	57..112	CDD:99751	35/54 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..253		37/76 (49%)
		Nuclear localization signal. /evidence=ECO:0000305|PubMed:27133716	189..192		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000305|PubMed:27133716	203..206		1/2 (50%)
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000269|PubMed:27133716	232..253		9/21 (43%)
CG10375	NP_651185.1	DnaJ	54..187	CDD:440252	64/132 (48%)
		DnaJ	54..109	CDD:99751	35/54 (65%)