Protein Alignment HSPA4L and Hsp70Bbb

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 193/709 - (27%)
• Similarity: 339/709 - (47%)
• Gaps: 111/709 - (15%)

Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:.||:|:..|.|||:.
  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65

Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161
            ..|:|.||.:|||.:..:....|:::.. ..|...:.|.|..|.:.||.|:::.|:|.|:|||:|
  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129

Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226
            ..|.:.:.|.||::|::|.|::|::...|..:||||.||::||.||.|||||:.|.    |.::
  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN----LKDE- 189

Human   227 RNVVFIDMGHSAYQVLVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKEN 290
            |||:..|:|...:.|.:...::|.| :|.:|..|.:|||.:||..||.:..:|||.|||.:::.|
  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254

Human   291 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAV 355
            .|||.||....|:.|:.:| ::::..:.|:......|..:|::||:||:|||.|......|::..
  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318

Human   356 MEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDISTTLNADEAVARGCALQCAILS--PA 417
            :..|.:.:..|..|.:|||:||||.|:..:.:||. |:::.::|.|||||.|.|:|.||||  .:
  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383

Human   418 FKVREFSITDLVPYSITLRWKTSFEDGSG--------ECEVFCKNHPAPFSKVITFHKKEPFELE 474
            .|:::..:.|:.|.|:      ..|...|        .|.:.|| ....||   |:...:|....
  Fly   384 GKIQDVLLVDVAPLSL------GIETAGGVMTKLIERNCRIPCK-QTKTFS---TYSDNQPGVSI 438

Human   475 AFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHS 539
            ..|.....:...:..:|:|.:..:.|...| ..:::|...::.:||.:|::
  Fly   439 QVYEGERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSA-------------- 488

Human   540 DAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK 604
                                                                         :.:.
  Fly   489 -------------------------------------------------------------KEMS 492

Human   605 KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTV 669
            .||.|:|.:.....   :|.|..::..:....|...:|:..::|..::||:|.||::.:..:...
  Fly   493 TGKAKNITIKNDKG---RLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQA 554

Human   670 YEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEE 728
            ....:...|.:.:.....:|..|| :......|:.:..|::||.::..||..|.  |::
  Fly   555 PAGKLDEADKNSVLDKCNETIRWL-DSNTTAEKEEFDHKMEELTRHCSPIMTKM--HQQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	142/383 (37%)
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	192/708 (27%)