Protein Alignment HSPA4L and Hsc70-2

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 199/738 - (26%)
• Similarity: 350/738 - (47%)
• Gaps: 136/738 - (18%)

Human    20 GSVPAARPSRGGMSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAK 84
            |.:||          :|||||.....:.|.::..:|.|||:..:|.||:.::.....|.||:.||
  Fly     2 GKIPA----------IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAK 56

Human    85 SQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVT 149
            :|:..|.:||:...|:|.||.|||..:|.:....|:::.. ..|...::|.:..|.:.||.|:::
  Fly    57 NQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEIS 120

Human   150 GMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 214
            .|:|.|::|.:|..|...|.|.|:::|::|.|::|::...|..:||||.||::||.||.|||||:
  Fly   121 SMVLTKMREIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGL 185

Human   215 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDE 278
            .|.     .:..|||:..|:|...:.|.|.:.::|.| :|.||..|.:|||.:||..||::|.:|
  Fly   186 DKN-----LKGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEE 245

Human   279 FKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCAS 343
            ||.|:|.::|.|:|||.||...||:.|:.:| ::::..|.|:.....:|..||::||:||:|...
  Fly   246 FKRKHKSDIKGNARALRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMD 309

Human   344 LLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFF-LKDISTTLNADEAVARGC 407
            |......|::..:..|.:.::.|..:.:|||:||||.:::.:...| .|.::.::|.|||||.|.
  Fly   310 LFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGA 374

Human   408 ALQCAILS--PAFKVREFSITDLVPYSITLRWKTSFEDGSG--------ECEVFCKNHPAPFSKV 462
            |:|.|||:  .:.::::..:.|:.|.|:      ..|...|        ...:.||.     .::
  Fly   375 AVQAAILTGVGSSQIQDLLLVDVAPLSL------GIETAGGVMTNLVERNARIPCKQ-----QQI 428

Human   463 ITFHKK-------EPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGI 520
            .|.:..       :.:|.|...|..:.:      :|:|.:..:.|...| ..:::|...:|..||
  Fly   429 FTTYSDNQNAVTIQVYEGERAMTKDNNL------LGTFNLTGIPPAPRG-VPQIEVAFDLNADGI 486

Human   521 FSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTG 585
            .:|.:                            |||                          .||
  Fly   487 LNVNA----------------------------KDN--------------------------STG 497

Human   586 AKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERND 650
            ...|..:|:.:.||::.       .||        |.|.:         ..|..::|..::||..
  Fly   498 KSEKITISNDKGRLSKA-------EID--------RMLSE---------AEKYKVEDDRQRERVQ 538

Human   651 AKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKY 715
            :||.:|.|:|..|..:.......::..:.||:........:||.::...: |:.:...|:|.::.
  Fly   539 SKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWLDKNSLAE-KEEFESHLKECQRI 602

Human   716 GQPIQMKYMEHEERPKALNDLGK 738
            ..||..|.  |..: |..:.:||
  Fly   603 CTPIMSKI--HGGK-KGKSSMGK 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	138/383 (36%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	199/738 (27%)