Protein Alignment HSPA4L and Hsp110

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 860
• Identity: 373/860 - (43%)
• Similarity: 539/860 - (62%)
• Gaps: 47/860 - (5%)

Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96
            |||:|||.|..:||:|.||||||||:||:||.|.||:.::...:.|.||.|||:|.|||::||:.
  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65

Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161
            |||:|.||.|:||.||.|...:|..::...:||.|:||.||.|::.|..||:|.||..||||||.
  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130

Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226
            .|::..|.||||:.|.|||:|||::::.|||:||||.|||||||||.|||||.||.||  .::||
  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193

Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291
            |||:|:|.|||:.|...|||.|||||:||:|:| .:|||:.|.||.|||..||:.:||||.|.|:
  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257

Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356
            ||.|||..|.|||||.||||::.||||||||::|:||||.|.|:|.|:|||.:|.|||...|.::
  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322

Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVARGCALQCAILSPAFKVR 421
            .::.||.:||.|:|||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||
  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387

Human   422 EFSITDLVPYSITLRWKTSFEDGSGECEVFCKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYP 486
            ||.:||:..|::.:.|.:......||.|:|.:.|.:|||:::|.::|.||.:...|.  .:||||
  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450

Human   487 DARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKN 551
            |..||.:.:::|.|...|:...||:|||:|.:||..::||:::||:..|    :|....|.:...
  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAE----EAAAAAEQAASE 511

Human   552 ENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGA-----------KTKSAVSDKQDRLNQTLKK 605
            |...:......:..:|.|:.:.|:   |:.::|..           :.|.......|:     ||
  Fly   512 EKPGDQTNNTGEPADGQQEAYCEN---EDDNNTSTASSPGGQGWAQRVKGWFGSGADK-----KK 568

Human   606 GKVKSIDLPIQSSLCRQLG---QDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRL- 666
            ...|:.:||::   |...|   .||.| |.:.|.|||..|:.|.||.|||||:||:|||.|::|
  Fly   569 KASKATELPLE---CTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQ 629

Human   667 GTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPK 731
            |..:|:::...:..|:.:.|.|.||||||||||..:.:|..:||.|.:...||:::..::|:.|.
  Fly   630 GGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPA 694

Human   732 ALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPV 796
            |.::|...|.:....:..:|....:||||..||...:.:....|.|||::.:....:...|.|..
  Fly   695 AFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSP 759

Human   797 VKVSEIVAKSKELDNFCNPIIYKPKPK------AEVPEDKPKANSEHNG--PMDGQSGTETKSDS 853
            |::|.:..:.:.|::..:.:|.:.|||      |..|:|  :||:|.||  |. ..||.:...|:
  Fly   760 VQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKD--EANAEQNGGEPA-ANSGDKMDVDN 821

Human   854 TKDSSQHTKSSGEME 868
            ...|:.....|.|:|
  Fly   822 NGQSAAGNDPSMEVE 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	222/381 (58%)
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	217/376 (58%)