Protein Alignment HSPA4L and Hsc70-1

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 199/698 - (28%)
• Similarity: 332/698 - (47%)
• Gaps: 105/698 - (15%)

Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96
            :..||||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|..|||.
  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68

Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161
            ..|:|.||.|||..||::....|:|: ...||...::|.|..|.:.|..|:|:.|:|.|::||:|
  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEV-FAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAE 132

Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226
            ..|...|.|.|:::|::|.|::|::...|..:||||.||::||.||.|:|||:.||     ....
  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ-----GTSE 192

Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291
            |||:..|:|...:.|.|.....|..:|.||..|.:|||.:||..||::|..||:.|:|.::.:|.
  Fly   193 RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNK 257

Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356
            |||.||...||:.|:.:| :::...:.|:.....:|..:.:.||:||:|...|......|:...:
  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKAL 321

Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDISTTLNADEAVARGCALQCAIL--SPAF 418
            ..|.:.:..|..|.:|||:||||.|:..:..||. |:::.::|.|||||.|.|:|.|||  ..:.
  Fly   322 RDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSE 386

Human   419 KVREFSITDLVPYSITLRWKTSFEDGSGECEVFCKNH---PAPFSKVI-TFHKKEPFELEAFYTN 479
            .|::..:.|:.|.|:      ..|...|......|.:   |...:::. |:...:|..|...:..
  Fly   387 AVQDLLLLDVTPLSL------GIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEG 445

Human   480 LHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPME 544
            ...:...:..:|.|.:..:.|...| ..:|:|...::.:||.:|   :.:||.
  Fly   446 ERAMTRDNNSLGKFELSAIPPAPRG-VPQVEVTFDIDANGILNV---TALEKS------------ 494

Human   545 TETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVK 609
                                                   ||         |::|:..|..||::.
  Fly   495 ---------------------------------------TG---------KENRITITNDKGRLS 511

Human   610 SIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQ-DKLEKERNDAKNAVEEYVYDFRDRLGTVY--E 671
            ..|:                ..:.|:.:...| |:.:::|.:|||.:|.|.:..|..|...:  .
  Fly   512 KEDI----------------ERMVNDAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSS 560

Human   672 KFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPI 719
            :| :|.|...:.....:|..|| :..:...:|.:..|.|||::...||
  Fly   561 RF-SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	145/384 (38%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	199/698 (29%)