Protein Alignment HSPA4L and Hsc70-3

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 706
• Identity: 193/706 - (27%)
• Similarity: 347/706 - (49%)
• Gaps: 118/706 - (16%)

Human    33 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISL-GSRTRAIGNAAKSQIVTNVRNTIH 96
            :|:|||||.....:.|.::|.:|.|||:..:|.||:.::. ....|.||:|||:|:.||..||:.
  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94

Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161
            ..|:|.||.:.|..||.:....|:::.: .|....:.|...:..:.||.|:::.|:|.|:|||:|
  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158

Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226
            ..|.|.|...|:::|::|.||:|::...|..:|||..:|::||.||.|:|||:.|:      |..
  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK------EGE 217

Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291
            :||:..|:|...:.|.:...:.|..:|:||..|.:|||.:||:.::|:|...:|.|...::::::
  Fly   218 KNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDN 282

Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356
            ||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|..:.||:||:|...|......|::.|:
  Fly   283 RAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVL 346

Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFF-LKDISTTLNADEAVARGCALQCAILSPAFKV 420
            |.|::.::|:..|.:|||:||||.|::.:..|| .|:.|..:|.|||||.|.|:|..:||.....
  Fly   347 EDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDT 411

Human   421 REFSITDLVPYSITLRWKTSFEDGSGECEVFCKNHPAPFSKVITFHKKEPFELEAFYTNLHEVP- 484
            ....:.|:.|.::      ..|...|   |..|  ..|.:.||...|.:.|...:  .|.|.|.
  Fly   412 DAIVLLDVNPLTM------GIETVGG---VMTK--LIPRNTVIPTKKSQVFSTAS--DNQHTVTI 463

Human   485 --YPDAR--------IGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHS 539
              |...|        :|.|.:..:.|...| ..:::|...::.:||..|::
  Fly   464 QVYEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------------- 513

Human   540 DAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK 604
                                    :::|                ||.|.|..:::.|:||..
  Fly   514 ------------------------EDKG----------------TGNKEKIVITNDQNRLTP--- 535

Human   605 KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTV 669
                                :| ::..|.:..|...:||..|||.:::|.:|.|.|..::::|.
  Fly   536 --------------------ED-IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGD- 578

Human   670 YEKF---ITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMK 722
            .:|.   ::.::.:||.:.::::..||.::.:..|:: |..:.::|:...||:..|
  Fly   579 KDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPVIAK 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	135/383 (35%)
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	192/704 (27%)