Protein Alignment HSPA4L and Grp170

DIOPT Version :10

• Sequence 1: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 903
• Identity: 272/903 - (30%)
• Similarity: 431/903 - (47%)
• Gaps: 97/903 - (10%)

Human    31 GMSVVGIDLGFLNCYIAVARSG-GIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 94
            |.:|:.:|||.....:.|...| .:|...|..|.|.|||.::....||.||..|:: |.....|:
  Fly    19 GAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQT-IGIKDPNS 82

Human    95 IHGF-KKLHGRSFDDPIVQTERIRLP-YELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLK 157
            .:|: ..|.|::.|:|||...|.|.| |.:...|..:..|..:...:|  |::|::...||.|.|
  Fly    83 AYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE--FSVEELVAQLLVKAK 145

Human   158 ETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPL 222
            :.::.::::|:.:||:::|.:|..|||.::::|||:|.|..|:|:|:..||||.||::.:.  .:
  Fly   146 QFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EI 208

Human   223 DEKPRNVVFIDMGHSAYQVLVCAFNKGK----------LKVLATTFDPYLGGRNFDEALVDYFCD 277
            :|..:..:|.|||.......|.::...|          ::||...:|..|||......|.||...
  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273

Human   278 EFKT--KYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQL 340
            ||..  |.|.:|..:.|||.:|::|..:||.::||| ::....||..:.|:|....:.|.:.|||
  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337

Human   341 CASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVAR 405
            |..|..|...||:..:..::|..:.|:.:.:.||.||:|.|:|.|.....:::...|||||:...
  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402

Human   406 GCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEV----FCKNHPAPFSKVITFH 466
            |...:.|.||..|||::|.:.|...:.:.:.::....||:...:|    |...:|.|..|||||:
  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467

Human   467 K-KEPFELEAFYTNLHEVPYPD---------ARIGSFTIQNV--------FPQSDG---DSSKVK 510
            | .:.||   ||.|     |.|         |.:||..:..|        ..:|..   |:..:|
  Fly   468 KHTDDFE---FYVN-----YADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIK 524

Human   511 VKVRVNIHGIFSVASAS-VIEKQNLEGDHSDAPMETE---------TSFKNENKDNMDKMQVDQE 565
            ....::..|||...... |.|||..|.|..:....::         |....|.|||.     :||
  Fly   525 AYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNS-----EQE 584

Human   566 E----GHQKCHAEHTPEEEIDHTGAKTKSAVSDKQD--RLNQTLKKGKVKSIDLPIQSSLCRQLG 624
            |    |.:...:|...:.:.:....:.||..|.|||  ..|:|:|...|||   |:......|..
  Fly   585 EAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKS---PVTYESQTQFV 646

Human   625 QDLLNS-YIENEGKMIMQDKLEKER---NDAKNAVEEYVYDFRDRLG-TVYEKFITPEDLSKLSA 684
            ..|:.| |.::..|:...:|.|::|   ..|.||:|.::.:.:.:|. ..|.|..|.|:..||.|
  Fly   647 VPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLA 711

Human   685 VLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEA 749
            .......|||||.||...::|.:||.:|||.......::.||||||:|:..|...|....|.:..
  Fly   712 ECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVT 776

Human   750 YRN--KD--ERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELD 810
            .||  ||  ...|.....|::.::|.|::..:||.::..||.||:...|..:.|.:|..|...||
  Fly   777 GRNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLD 841

Human   811 N----FCNPI-IYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKS-DSTKDSSQHTK 862
            .    ..|.| |:|||.|....::|.|   |......| ||.:||| |:.:...|.||
  Fly   842 REVKYLVNKIKIWKPKVKPAAEKEKKK---EEEVVASG-SGDDTKSEDAEQQQEQATK 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	123/396 (31%)
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	122/393 (31%)
		PTZ00121	<546..917	CDD:173412	110/362 (30%)
		TAF4	<572..>627	CDD:461598	16/59 (27%)