Protein Alignment MTF2 and Pcl

DIOPT Version :10

• Sequence 1: NP_031384.1
• Gene: MTF2 / 22823
• HGNCID: 29535
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_476672.1
• Gene: Pcl / 37069
• FlyBaseID: FBgn0003044
• Length: 1043
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 192/738 - (26%)
• Similarity: 273/738 - (36%)
• Gaps: 229/738 - (31%)

Human    39 AKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWV----LWK-----DIQ 94
            |..||..:...:||..:.:||.||||||  |:.......|.|:|.|:.|.    |.|     .|.
  Fly   344 APSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSIT 406

Human    95 TGATG-----------SGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEK 148
            .|..|           ||.| |..|:.  |:..:.:.||::||:|||:.|....:..|.|
  Fly   407 AGGGGASTTESTNTSPSGPM-CVACKR--SDIEDVVEICERCGRGYHRGCTVEIVTGSGI----- 463

Human   149 WLCRQC---------VFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYC 204
            |.|::|         |....||..|..::             |||....|.||..|:.|.:|.||
  Fly   464 WSCKRCAKPMKMQQPVSHKITKPAGICRQ-------------LPYHADKLSWDEKHRVNEEQIYC 515

Human   205 YCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDI 269
            |||.||.:...|||||||:.|||..|:|..:|.:|.||.|:.|.|:||::|.|:::|:.::|||:
  Fly   516 YCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDV 580

Human   270 AHLCLYNLSVIHKKKY---------FDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALN 325
            .|:.||||.....:||         |..|......|.|.|..|        |::...|.:.:.|.
  Fly   581 LHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTL--------PETALMERLKQTLK 637

Human   326 DYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNV---------------AFK----AEKEPEGTS-- 369
            ||...|:.|:|.|:....:.||...||..|.|               .||    .|:..||.:
  Fly   638 DYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANEL 702

Human   370 --------HEFKIKGRKASKPISDSREVSNGIEKKGKKKSV------------------------ 402
                    :||........:...|...:...|| |.||::.
  Fly   703 PKRVPKDVYEFNTDEDDPVETSEDEIPIKQIIE-KAKKQAAQKADKHDELPLKPDLADDNANDGD 766

Human   403 -GRPPGPYTRKMIQKTAEPLLDKESISENPTLDLP---------CSIGRTEGTAHSSNTSDVD-- 455
             |:.|.|         ..||||..|..:.....|.         |.:...|.::.|..||.:|
  Fly   767 PGKLPAP---------IPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLI 822

Human   456 -------------FTGASSAKETTSSSIS--------------------------------RHYG 475
                         |..|:..|.:...|||                                |...
  Fly   823 IPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLS 887

Human   476 LSD---------SRKRTRTGRS-------------------------WPAAIPHLRRRRGRLPRR 506
            ..|         .|:|||...:                         .|.|.|..:...|||.|:
  Fly   888 AKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQ 952

Human   507 ALQTQNSEIVKDDEGKEDYQFDELNTEILNNLADQELQLNHLKNSITSYFGAA-GRIACGEKYRV 570
            ..|.|:     ..:.:.:.......:...|.:......:..||.|:..|||.| .||..||.:.:
  Fly   953 RPQKQS-----PSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAI 1012

Human   571 LARRVTLDGKVQYLVEWEGATAS 593
            .|:|...:|:|||||||.|.||:
  Fly  1013 RAKRRMGNGQVQYLVEWGGDTAT 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTF2	NP_031384.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		Tudor_MTF2	45..98	CDD:410521	20/61 (33%)
		PHD1_MTF2	104..156	CDD:277053	16/60 (27%)
		PHD2_MTF2	203..254	CDD:277055	28/50 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..411		15/89 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..486		20/126 (16%)
		Mtf2_C	544..591	CDD:464077	22/47 (47%)
Pcl	NP_476672.1	PRK12323	<13..107	CDD:481241
		Tudor_dPCL-like	350..401	CDD:410523	18/52 (35%)
		PHD_SF	426..469	CDD:473978	16/50 (32%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	28/50 (56%)
		Mtf2_C	985..1033	CDD:464077	22/47 (47%)