Protein Alignment RASA3 and RasGAP1

DIOPT Version :10

• Sequence 1: XP_047286110.1
• Gene: RASA3 / 22821
• HGNCID: 20331
• Length: 878
• Species: Homo sapiens
• Sequence 2: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Alignment Length: 958
• Identity: 340/958 - (35%)
• Similarity: 504/958 - (52%)
• Gaps: 178/958 - (18%)

Human    87 SAQGRRTL-------------SPAAQ-ALGPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIG 137
            |.||.|.:             :|..: .|.||:||:...:|||.||:|:.|::|||: ::|..||
  Fly    66 STQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRRFRYLTIYLWDRDM-KQDKPIG 129

Human   138 KVAIQKEDLQKYHNRDTWFQLQHVDADSEVQGKVHLEL--------------------------- 175
            |:||::|:|..|:::|.||.|:.||.||||||.|::|:
  Fly   130 KIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQN 194

Human   176 -------------------------RLSEVITDTGVVCHKLATRIV-----------ECQGLPIV 204
                                     |.|.....:......|.||..           :.|..||:
  Fly   195 LPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFGHVHHPPSQTQHFPII 259

Human   205 N-----------------------------------GQCDPYATVTLAGPFRSE-AKKTKVKRKT 233
            |                                   |.|||:...|.....:.: .::||.::||
  Fly   260 NTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQVTRRTKQRKKT 324

Human   234 NNPQFDEVFYFEV-------TRPCSYSKKSHFDFEEE-----------DVDKLEIRVDLWNASNL 280
            .:|:|||..||::       :...:.|.||....|..           ..|.:||.|.:|:.::.
  Fly   325 VDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHG 389

Human   281 KFGDE-FLGELRIPL--KVLRQSSSYEAWYFLQPRD--NGSKSLK----------------PDDL 324
            ...|: ||||:|:|:  |..:|:.:..|||:||||.  :.|:||.                ...:
  Fly   390 AMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTI 454

Human   325 GSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHY 389
            ||||||:.||.||||....|..|.:|||:|.|..|::.||..||||:...|.|.|.||||||.|.
  Fly   455 GSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHT 519

Human   390 GRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPC 454
            .|:.|.|.|:|..|:....||.||||||:|.||.:||.|:|:|:||||.||:|.:.:|....|||
  Fly   520 ERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPC 584

Human   455 EIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRY 519
            ||||.|:||...::.|:.||:.||:|||.|||:|...||.|:|.||..|||.|.:.|..:.:|||
  Fly   585 EIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRY 649

Human   520 TAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSL--SKSKSASFKESYM 582
            :.||.||||||||||||.|.||.||....|.||||||||||||:|:||:|  |:|...:.||.:.
  Fly   650 SVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFT 714

Human   583 ATFYEFFNEQKYADAVKNFLDLIS----SSGRRDPKSVE----QPIVLKEGFMIKRAQGRKRFGM 639
            ...|:.|..:::.||||:||::||    :|....|.:..    :|::||||.|.|....|||||
  Fly   715 VELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFG- 778

Human   640 KNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQAN 704
            :.||:|.||||.|..:|.||||.||:..||::.|.:||:|:::||||:|.|:::..:|:|.:|..
  Fly   779 RQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT 843

Human   705 NCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANIQLD-- 767
            ||||.::|.|:|.|:...|..|:..:||||::||.:.||....:::|||...........|:|
  Fly   844 NCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLV 908

Human   768 --IDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQEEYSTFV-------IDDPQ---ET 820
              :|...:.:||::|....||.||.:.:...........:.::::..|       ...||   |.
  Fly   909 TALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEF 973

Human   821 YKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIR 868
            .:|::::.....|::::|..||:...::.||||::.||||.::.:.:|
  Fly   974 KRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPIGDDNYWHMMR 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RASA3	XP_047286110.1	C2	<99..177	CDD:472691	38/130 (29%)
		C2B_RasA3	190..332	CDD:175977	56/227 (25%)
		RasGAP_RASA3	341..609	CDD:213336	140/273 (51%)
		PH_GAP1_mammal-like	606..730	CDD:241522	55/131 (42%)
		BTK	723..758	CDD:128417	13/34 (38%)
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	43/103 (42%)
		C2B_RasA3	280..462	CDD:175977	49/181 (27%)
		RasGAP_GAP1_like	473..740	CDD:213330	140/266 (53%)
		PH_GAP1-like	763..867	CDD:269950	50/104 (48%)
		BTK	862..897	CDD:128417	13/34 (38%)