Protein Alignment RASA3 and vap

DIOPT Version :10

• Sequence 1: XP_047286110.1
• Gene: RASA3 / 22821
• HGNCID: 20331
• Length: 878
• Species: Homo sapiens
• Sequence 2: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 146/547 - (26%)
• Similarity: 229/547 - (41%)
• Gaps: 109/547 - (19%)

Human   155 WFQLQHVDADSEV---QGKVH-------LELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQCD 209
            |........||::   |.||.       |.|.:.|        .|:|..::|.           .
  Fly   476 WINSLKAQCDSQLSRAQKKVSRLRELRCLNLHVLE--------AHRLPFKLVP-----------H 521

Human   210 PYATVTLAGPFRSEAK--KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRV 272
            ||.:::|     ::.|  ||:|| ....|.::|.|..:...|              ||..|.|.:
  Fly   522 PYCSISL-----NQVKVGKTRVK-IAPEPVWEEEFVLDDVPP--------------DVVSLTITL 566

Human   273 DLWNASNLKFG-DEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKP-DDLGSLRLNVVYTE 335
                .|..|.| |..:.||.|.|..|:.....|.||.|       ..:.| .:.|||||.:.|.:
  Fly   567 ----ISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL-------TGMTPMGEWGSLRLRMRYLD 620

Human   336 DHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVC-REKQEAAVPLVRLFLHYGRVVPFISAI 399
            |.:...:.||||:.|||:|      ...|...|.|:| .::...|..|:|:|....|....|..:
  Fly   621 DLIMPCEEYSPLQQLLLES------ELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRML 679

Human   400 ASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDG 464
            ..|||.|..:..|:|||.|||:..:|..|:.....:|...:...::.|.:|.:..|::|.|:...
  Fly   680 CQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVN 744

Human   465 ENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLR 529
            ::...|.|.|.|.:|.|..:|..|..:||..:..|...|::|...::..:..||...||.|||||
  Fly   745 DDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLR 809

Human   530 FFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 594
            ...||:|:|..|.|.........:|:|.:::|.:|.|.:|.:...   ||.||.....|..:.|.
  Fly   810 LLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGG---KEQYMEVVNPFILKNKE 871

Human   595 ADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRA-------QGRKRFGMKNFKKRWFRLTNH 652
            ...|  |||.:||.  .||   .||:    |..::::       .||:...:.:.      ..:|
  Fly   872 RMIV--FLDQLSSV--NDP---NQPL----GMFVEQSTNLNSQDTGRELATLHHI------CVSH 919

Human   653 EFTYHKSKGDQPLYSIPIENILAVEKL 679
            ....|:           :.|||:::||
  Fly   920 SQELHE-----------LSNILSIKKL 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RASA3	XP_047286110.1	C2	<99..177	CDD:472691	8/31 (26%)
		C2B_RasA3	190..332	CDD:175977	37/145 (26%)
		RasGAP_RASA3	341..609	CDD:213336	83/268 (31%)
		PH_GAP1_mammal-like	606..730	CDD:241522	16/81 (20%)
		BTK	723..758	CDD:128417
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	1/7 (14%)
		C2_Ras_p21A1	499..622	CDD:176045	42/172 (24%)
		RasGAP	620..954	CDD:470620	98/353 (28%)