DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment COPG1 and gammaCOP

DIOPT Version :9

Sequence 1:NP_057212.1 Gene:COPG1 / 22820 HGNCID:2236 Length:874 Species:Homo sapiens
Sequence 2:NP_001263145.1 Gene:gammaCOP / 43717 FlyBaseID:FBgn0028968 Length:897 Species:Drosophila melanogaster


Alignment Length:881 Identity:531/881 - (60%)
Similarity:656/881 - (74%) Gaps:22/881 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     7 KKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFF 71
            :||:|..|.||.:|:|||::||||.|.|||||:|||||.||||||||||||||.|...|||:.||
  Fly     7 EKDDEEDGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFF 71

Human    72 AMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTM 136
            ||||||||.|..||||.||.|||:|.|||||||||||||||||||||.||..|:||||.|||:||
  Fly    72 AMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTM 136

Human   137 LQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLY 201
            |||:||||||.||||..:||.:||||||.|...:.||||||.||||||.:|||||||||||||||
  Fly   137 LQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLY 201

Human   202 HVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQLEEED----GSRDSPLFDFIESCLRNK 262
            |:||:|||||:|:::|:||..||||:|.||:||:|.|.:||||    ...|||||.|||||||:|
  Fly   202 HIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHK 266

Human   263 HEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNL 327
            .|||:||||.|||||...:.:.|:||.|:||||||||||.||:|||||||||||.||:|||.|||
  Fly   267 SEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNL 331

Human   328 DLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPR 392
            |||.|:||||||:||||||||||||:|||::|||||||:|::||||||||||||||.|||.||||
  Fly   332 DLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPR 396

Human   393 KHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILH 457
            ||.||||||..|||||||.|||.:|||.||:|||||:::||:|||||||||||||...||.||||
  Fly   397 KHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILH 461

Human   458 LLGQEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDN 522
            |||:|||....||||||||||||:||...|||.||:|:|:|||....:|.:|||||.||.||.|:
  Fly   462 LLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPDD 526

Human   523 EVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLA--TAP 585
            |||||||:||::|..::..|...||:.....|:..||::|.::.....:..||:..||.|  ..|
  Fly   527 EVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKP 591

Human   586 MAEQR----TESTPITAVKQPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEY 646
            :....    |.|.|     :|.|:  ||:|....:||.:|..:.|||:.:|: .|:.||||||||
  Fly   592 VIANDVMLVTSSAP-----RPPKI--TREEESAARLAQLPGIQVLGPIHRST-APIQLTESETEY 648

Human   647 VIRCTKHTFTNHMVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVA 711
            .::|.||.|..|:||||||.|||:||.||||.|::...|.:.....:|...||||...|.:.:|.
  Fly   649 TVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVE 713

Human   712 LPKEDPTAVACTFSCMMKFTVKDCDPTTGETD-DEGYEDEYVLEDLEVTVADHIQKVMKLNFEAA 775
            .|.:...::| ||...::|.||||||.|||.: :|||:|||:|||||:||||.|||..|.||:.:
  Fly   714 FPPDAANSIA-TFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVS 777

Human   776 WDEVGDE--FEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGH 838
            ||....|  .:.|:||.||.:.||::||..|||.||:.....|:.||:..:.||||.:|.||||.
  Fly   778 WDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGA 842

Human   839 DILVRSRLLLLDTVTMQVTARSLEELPVDIILASVG 874
            :||||::|.|.:.||:.:|.||.::...::|.|::|
  Fly   843 EILVRAKLALSEGVTLNLTVRSTDQDVAELITAAIG 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COPG1NP_057212.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 6/13 (46%)
SEC21 7..869 CDD:227565 528/874 (60%)
HEAT 1 64..101 26/36 (72%)
HEAT 2 283..320 28/36 (78%)
HEAT repeat 288..313 CDD:293787 20/24 (83%)
HEAT 3 322..355 27/32 (84%)
HEAT repeat 323..354 CDD:293787 26/30 (87%)
HEAT 4 356..392 28/35 (80%)
HEAT repeat 363..397 CDD:293787 27/33 (82%)
HEAT repeat 398..423 CDD:293787 18/24 (75%)
HEAT repeat 435..461 CDD:293787 21/25 (84%)
HEAT repeat 471..501 CDD:293787 21/29 (72%)
Interaction with ZNF289/ARFGAP2. /evidence=ECO:0000269|PubMed:14690497 609..874 124/267 (46%)
gammaCOPNP_001263145.1 SEC21 11..877 CDD:227565 528/874 (60%)
HEAT repeat 402..427 CDD:293787 18/24 (75%)
HEAT repeat 439..465 CDD:293787 21/25 (84%)
HEAT repeat 475..505 CDD:293787 21/29 (72%)
HEAT repeat 512..538 CDD:293787 19/25 (76%)
COP-gamma_platf 620..761 CDD:285908 70/142 (49%)
Coatomer_g_Cpla 763..877 CDD:292991 50/113 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145439
Domainoid 1 1.000 734 1.000 Domainoid score I102
eggNOG 1 0.900 - - E1_COG5240
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1008 1.000 Inparanoid score I286
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53896
OrthoDB 1 1.010 - - D207992at33208
OrthoFinder 1 1.000 - - FOG0002163
OrthoInspector 1 1.000 - - otm40884
orthoMCL 1 0.900 - - OOG6_101348
Panther 1 1.100 - - O PTHR10261
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R230
SonicParanoid 1 1.000 - - X1625
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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