DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MRAS and RAS1

DIOPT Version :9

Sequence 1:	NP_001078518.1	Gene:	MRAS / 22808	HGNCID:	7227	Length:	208	Species:	Homo sapiens
Sequence 2:	NP_014744.1	Gene:	RAS1 / 854268	SGDID:	S000005627	Length:	309	Species:	Saccharomyces cerevisiae

Alignment Length:	163	Identity:	96/163 - (58%)
Similarity:	129/163 - (79%)	Gaps:	1/163 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    14 YKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMR 78
            ||:||||.||||||||||||.|..||.:|||||||||.|...||::.:|||:||||||||:||||
Yeast    11 YKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMR 75

Human    79 EQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKE 143
            |||||||:|||:|||||.:.||:.:..::|.|.||||.:..|:::|.||:||.:.|:::.|.|..
Yeast    76 EQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLR 140

Human   144 MATKHNIPYIETSAKDPPLNVDKAFHDLVRVIR 176
            :|.:.|.|::|||||. .:|||:||:.|:|::|
Yeast   141 LAKQLNAPFLETSAKQ-AINVDEAFYSLIRLVR 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRAS	NP_001078518.1	M_R_Ras_like	12..176	CDD:133345	95/161 (59%)
MRAS	NP_001078518.1	Effector region	42..50		7/7 (100%)
RAS1	NP_014744.1	small_GTPase	9..172	CDD:197466	95/161 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910