Protein Alignment TFEC and RTG3

DIOPT Version :10

• Sequence 1: XP_011514265.1
• Gene: TFEC / 22797
• HGNCID: 11754
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_009447.1
• Gene: RTG3 / 852171
• SGDID: S000000199
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 353
• Identity: 85/353 - (24%)
• Similarity: 137/353 - (38%)
• Gaps: 107/353 - (30%)

Human    58 SSQLPSFTRVPAHLESSA-------------RPQLQKAQRQKVNSFMTLDHQIINPTLKWSQPAV 109
            :||.|:.:.:....||.:             ||..|       ||..::....:.     |..::
Yeast    86 NSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQ-------NSISSIGQGPLR-----SSYSM 138

Human   110 PSGGPLVQHAHTTLDSDAGL-TENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSP 173
            ....|:.:..:|.|....|| .|.|...|...|.:|.     |.::.:|:    ||......:|.
Yeast   139 AYDSPVDRAMNTPLQQQEGLKAELPHDFLFQHGTDDT-----MYNLTDDL----SSSLSSSINSD 194

Human   174 LLMQRTLSGSILDVYSGEQGISPINMGLTSAS--------CPSS------------------LPM 212
            ::...|        ||.....:|.::|..|.|        .|||                  .|.
Yeast   195 MMTPNT--------YSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTPR 251

Human   213 KR--EITETDTRALA---------------KERQKKDNHNLIERRRRYNINYRIKELGTLIPKS- 259
            .|  .|:...|..:.               |.|:|::.||.:|||||..|..:|||||.|:|.|
Yeast   252 TRHTSISSNMTENIGPGSVPKILGGLTSDEKLRRKREFHNAVERRRRELIKQKIKELGQLVPPSL 316

Human   260 -NDPDM----RWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQART 319
             |..|:    :.|||.||..:|||:::|.:    ..|::.|:||      .||.:|:|||.:.
Yeast   317 LNYDDLGKQIKPNKGIILDRTVEYLQYLAE----ILEIQARKKK------ALLAKIKELEEKK-- 369

Human   320 HGLPTLASLGTVDLGAHVTKQQSHPEQN 347
               .::|:|.......|.:..|::.|.:
Yeast   370 ---SSVAALSPFTNNHHASSGQNNSENS 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEC	XP_011514265.1	bHLHzip_TFEC	226..310	CDD:381495	36/89 (40%)
		DUF3371	315..434	CDD:463372	5/33 (15%)
RTG3	NP_009447.1	bHLHzip_USF_MITF	289..349	CDD:381393	27/63 (43%)