Protein Alignment TFEC and Mitf

DIOPT Version :10

• Sequence 1: XP_011514265.1
• Gene: TFEC / 22797
• HGNCID: 11754
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 149/526 - (28%)
• Similarity: 230/526 - (43%)
• Gaps: 166/526 - (31%)

Human     1 MLQALTGLQFQLKEQLGEKERRLQISQEISAHRTEFHMQFSYKPVLHRLVPARPQIYSS-----Q 60
            :||..|.|:...:..:.:|::. |:.|.:|.         |:|          |.::.|     :
  Fly   276 VLQVSTVLENPTRYHVIQKQKN-QVRQYLSE---------SFK----------PSMWGSHTSEIK 320

Human    61 LPSFTRVPAHLESSARPQLQKA---QRQKVNSF---MTLDHQIINPTLKWSQPAVPSGGPLVQ-- 117
            |.:.:....:|::|:   |||.   ..::.|.|   ..:..:.|.|: ..:.|..|.||..|:
  Fly   321 LANNSASTGNLQNSS---LQKGICDPLERTNRFGCDSAVSAKRIMPS-DDAMPISPFGGSFVRCD 381

Human   118 ------------HAHTTLDSDAGLTENP-LTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEG 169
                        ::|     .||..||. .|..|.:.|.:                  ||.....
  Fly   382 DINPIEPTVLRPNSH-----GAGEPENAHRTAQLGLSKAN------------------SSLSSTR 423

Human   170 ADSPLLMQRTLSGSILDVYSGEQGISP-INMGLTSASCP--------------------SSLPMK 213
            :.|.::....:|.:...:.|....||| ::...||.|.|                    |.|.:|
  Fly   424 SSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIK 488

Human   214 RE---ITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDP------DMRWNKG 269
            :|   :|:.:..||||:||||||||:||||||:|||.||||||||:||.:|.      |:|.|||
  Fly   489 QEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKG 553

Human   270 TILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLG 334
            ||||:||:|||.|:.|..|.|:.|.||:::|..||:|:.||:|||:||::||:  |.|..
  Fly   554 TILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGI--LLSEN----- 611

Human   335 AHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDG--- 396
             |:| ..|.|.|   .|.:..::|  |:.....::: |..|:.           |:.|.:||
  Fly   612 -HLT-SLSAPTQ---PYLKSFSLS--PTASRSRRSL-FDQPVE-----------KKIQVIDGADG 657

Human   397 ---------MLLDDTISPFGTDPLLSATS---PAVSKESSR----------------------RS 427
                     .:.|...:..|.||:||:.|   .|....||:                      :|
  Fly   658 NMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKS 722

Human   428 SFSSDD 433
            |.:|||
  Fly   723 SLASDD 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEC	XP_011514265.1	bHLHzip_TFEC	226..310	CDD:381495	54/89 (61%)
		DUF3371	315..434	CDD:463372	35/156 (22%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	11/54 (20%)
		bHLHzip_MITF_like	504..577	CDD:381403	47/72 (65%)