DRSC/TRiP Functional Genomics Resources

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Protein Alignment TFEC and Tfec

DIOPT Version :10

Sequence 1:XP_011514265.1 Gene:TFEC / 22797 HGNCID:11754 Length:437 Species:Homo sapiens
Sequence 2:NP_071774.1 Gene:Tfec / 26296 RGDID:3846 Length:317 Species:Rattus norvegicus


Alignment Length:347 Identity:250/347 - (72%)
Similarity:272/347 - (78%) Gaps:30/347 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    91 MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVI 155
            |||||::.:.|||.:||...|..||.:|...:.|||||...||.|..||:||||...:|.     
  Rat     1 MTLDHRLFSQTLKRAQPLAASCMPLAEHGPRSPDSDAGCAGNPFTNPLALGKEDGVVEWR----- 60

Human   156 EDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETD 220
                                    |||||||||||||||||:|.||.:|||||.||||:||.|||
  Rat    61 ------------------------LSGSILDVYSGEQGISPVNTGLMNASCPSILPMKKEIAETD 101

Human   221 TRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKE 285
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||:||||||||
  Rat   102 TRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDIRWNKGTILKASVDYIKWLQKE 166

Human   286 QQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVD 350
            |||||||||||||||.|||:|:|||||||||||.||||.||||||.|.|.|:||||:|.|:|||.
  Rat   167 QQRARELEHRQKKLEHANRQLMLRIQELEIQARAHGLPILASLGTADFGTHITKQQTHSEKNSVG 231

Human   351 YCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSAT 415
            .|||||.|||.|||..:||:|||||||:|||||||||||||||||||||.|||.||||||||||.
  Rat   232 CCQQLTPSQGTSPEFYEQAVAFSDPLSHFTDLSFSAALKEEQRLDGMLLSDTICPFGTDPLLSAI 296

Human   416 SPAVSKESSRRSSFSSDDGDEL 437
            ||||||.|| |||.||:|||||
  Rat   297 SPAVSKASS-RSSLSSEDGDEL 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TFECXP_011514265.1 bHLHzip_TFEC 226..310 CDD:381495 78/83 (94%)
DUF3371 315..434 CDD:463372 93/118 (79%)
TfecNP_071774.1 Necessary for transcriptional transactivation. /evidence=ECO:0000250 1..90 53/117 (45%)
bHLHzip_MITF 99..202 CDD:381496 96/102 (94%)
DUF3371 196..300 CDD:463372 82/103 (80%)
Necessary for transcriptional transactivation. /evidence=ECO:0000250 242..317 62/75 (83%)

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