Protein Alignment TFEC and hlh-30

DIOPT Version :10

• Sequence 1: XP_011514265.1
• Gene: TFEC / 22797
• HGNCID: 11754
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001023411.1
• Gene: hlh-30 / 177157
• WormBaseID: WBGene00020930
• Length: 524
• Species: Caenorhabditis elegans
• Alignment Length: 413
• Identity: 113/413 - (27%)
• Similarity: 174/413 - (42%)
• Gaps: 85/413 - (20%)

Human    91 MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVI 155
            |...||::...::..:.:.||.|....|......:..|:..       ..|.|.|:.      :|
 Worm   109 MQQTHQMLFGNIQPPRGSPPSDGSDKIHRFGESPTPGGVGG-------VFGTELDDL------II 160

Human   156 EDIIGMESSFK-EEGADSPLL--------MQRTLSGSILDVYSGEQGISPINM---------GLT 202
            ::::|||...: ..||..|:.        |.|.:.|:.....||..| |||.:         .:.
 Worm   161 DELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSG-SPITIPNAMSNNFRQVV 224

Human   203 SASCP-SSLPMKREI-----------TETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTL 255
            |:|.| ||:.:::.|           .:.|.....::|:|||.||:||||||||||.||||||.:
 Worm   225 SSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQM 289

Human   256 IPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELE------ 314
            :||:...||:.|||||||||.:||:.|||::::|.:.:.:||.||....:...|::|||
 Worm   290 LPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQ 354

Human   315 -IQARTHGLPTLASL--------------GTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPE 364
             :|.....||.:..:              .....|:.|:......|..:.....|:|......|.
 Worm   355 GVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPN 419

Human   365 LCDQAIAFSD---------PLSYFTDL-SFSAALKEEQRLDGMLLDDTISPFGTDPLLSATS--P 417
            ......|.||         |..|.|.. :.|..|........:::||.......|||:|:..  |
 Worm   420 NFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHP 484

Human   418 AVSKESSR--------RSSFSSD 432
            :....||:        .|.||.|
 Worm   485 SPHFHSSQMSPDIHWDASGFSPD 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEC	XP_011514265.1	bHLHzip_TFEC	226..310	CDD:381495	45/83 (54%)
		DUF3371	315..434	CDD:463372	30/152 (20%)
hlh-30	NP_001023411.1	bHLHzip_MITF_like	260..328	CDD:381403	41/67 (61%)