DRSC/TRiP Functional Genomics Resources

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Protein Alignment NID2 and Ndg

DIOPT Version :10

Sequence 1:XP_005267462.1 Gene:NID2 / 22795 HGNCID:13389 Length:1402 Species:Homo sapiens
Sequence 2:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster


Alignment Length:1607 Identity:413/1607 - (25%)
Similarity:598/1607 - (37%) Gaps:523/1607 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    10 PVLSS--LPVLLLLPLLM-----------LRAAALHPDELFPHGESWGDQLLQEGDDESSAVVKL 61
            |...|  |..|||..:::           |||:.|:.   |..|......||.:||.| :.|::|
  Fly     2 PTFGSKLLACLLLSSVILVSGQFEHYLDSLRASELYE---FEDGSLGSIHLLPKGDSE-TIVLQL 62

Human    62 ANPLHFYEARFSNLYVGTNGIIS-TQDFPRETQYVDYDFPTDFPAIAPFLADIDTS---HGRGRV 122
            ..|:|||..::..||:.||||:: ..:||   :|::..||.::.:||.|.:::|||   .|....
  Fly    63 EQPIHFYGEQYEQLYINTNGILTFNSEFP---EYLNQPFPLEYASIAAFYSNVDTSFSDEGTSIS 124

Human   123 LYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLA 187
            |: |....::|..|:..||..|...:.|......:|||..||.::.      .:..|||||..|.
  Fly   125 LF-ESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDS------KTDRLNTFQVALI 182

Human   188 SDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLP---ARVGFCRGEADDLKSEGPYFSLT-STE 248
            ::...::..|:||..||.:|     :.....|.||   |:.||       :..:|.:::|. |..
  Fly   183 ANEQSTFVQFIYPDGGLNWL-----QGETAGLGLPDIRAQAGF-------VAEDGRFYTLNGSGS 235

Human   249 QSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATALESDYNED 313
            ::.:.|.:.:|||:||||.|.:   :|::|                                   
  Fly   236 ENARFLSESTNLGVPGVWLFEV---APIEN----------------------------------- 262

Human   314 NLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEGRISPPDSDLSSPLHPTPTYWP 378
                                                                             
  Fly   263 ----------------------------------------------------------------- 262

Human   379 FYPETESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPE 443
                                                |:..|||                      
  Fly   263 ------------------------------------EQNVRSP---------------------- 269

Human   444 NGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTYN 508
                                                                    .|.|..|.:
  Fly   270 --------------------------------------------------------DNAESLTES 278

Human   509 AANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHLHVGHTP 573
            .|...:|:.:..||...|.|.|.|.|:||.|.|.||||||.||....|.||.|.::|.|:  ..|
  Fly   279 PALALSCQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGELN--KQP 341

Human   574 VHFTDVDLHAYIVGNDGRAYTAISHI-PQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGA 637
            |. .:..|.:|:|.::||.||.|:.: |:..||..|.| |:.....||||....|..||:.|.|.
  Fly   342 VS-EEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVL-PLLTTVPWLFAKSVGGVANGYQLTGG 404

Human   638 AFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYS-D 701
            .:||...:.|..| |.:.:.||.|||:..:.||:|..|.|:||.|:|:....:..|.|.|.:. .
  Fly   405 VYTHVSRLQFDSG-ENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERP 468

Human   702 STVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVC-RHAPRHPSFPTTQQLNVDRVFALYNDEER 765
            ..:.|....:.::|  ...:....::.|.|.|:.| |.....||.....| .:.:|...|.:.::
  Fly   469 GELKSVQVLNINIT--EEQRVLGLQVEQRILYRSCLRDDEADPSATKVLQ-KISKVALDYVERDQ 530

Human   766 VLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRN--- 825
            .||....:::|...|      .|.|.||:..|...:.|.|.... |.|:|..|:  |.|.|.   
  Fly   531 ALRIGAMSKVGVTPE------SNACNDGTADCVENSVCVPYEDT-YRCDCYHGFAAQLDERGVEV 588

Human   826 CVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI-------LITPPA------- 876
            |:|.:|||||.|.|..|:||.|..|.:.|.|..|:|  .:.:.|:       :..|||       
  Fly   589 CLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFE--GNGYRCLSNSTADNIEYPPAVEGQAEP 651

Human   877 ------NPC-------------EDGSH---TCAPAGQARCVHHGGSTFSCA-----------CLP 908
                  ||.             ||..:   ...|..:.:...|....:.|:           |..
  Fly   652 TSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPDECYRCSKDADCYQGRCTCHE 716

Human   909 GYAGDGHQCT----------------------DVD-------ECS-------------------- 924
            |:.|||:.||                      |||       ||.                    
  Fly   717 GFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDALGECRCPYGYELSEDSQRCTYVQEF 781

Human   925 -------------ENRCHPAATC--YNTPGSFSCRCQPGYYGDGFQCIP--DSTSSLTP------ 966
                         :..||..|||  |.......|.||||:.|||:.|.|  |.:.::.|      
  Fly   782 DGERNADLIPCDVDENCHINATCNWYGQELRHICTCQPGFRGDGYNCDPISDDSCAIRPDICDVH 846

Human   967 --CEQQQR----HAQAQYAYPGARF------------HIPQ---CDE-----QGNF--------L 997
              |..::.    ..|.|..|.|..|            |..:   ||:     |.:|        :
  Fly   847 ADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFCDDGVCRCQADFERDVSDRCV 911

Human   998 PL-QCH----GSTGFC-W----------CVDP-DGHEVPGTQTPPGS--TPPHCG--PSPEPTQR 1041
            |. :|.    ||...| |          |:|. .|..:.|..:.|.|  ...:||  .:.|||:.
  Fly   912 PAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTGCTSKPLSCHVLNNCGIHATCEPTED 976

Human  1042 PPTI-CERWRENLLEHYGGTPRDDQYV-----------PQCDDLGHFIPLQCHGKSDFCWCVDKD 1094
            |... |:     .:..:.|    |.||           ..||     :..||...:....||...
  Fly   977 PANYECQ-----CIAGFKG----DGYVCIEEQNCLNNPTLCD-----MNAQCRSTNSGLVCVCNQ 1027

Human  1095 GREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDA 1159
            |....|:..|.               |.....|        ||:.:||..|..:||||..::..:
  Fly  1028 GFFGNGSLCQE---------------RQHQDSD--------FLIVSQGVMIARVPLNGRNVRPIS 1069

Human  1160 AKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIR 1224
            .       ..:.:|:|.||.|..|||.|::.:.|.....: |.:....:.:.:.||||:|||.|.
  Fly  1070 V-------AQMAIGLDKDCVEGRVYWGDISTKKIVSTKYD-GTDLRPFITTDIESPEGIAIDVIS 1126

Human  1225 RTMYWTDSVLDKIESALLDG-SERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD 1288
            |.:||.||..|.||.|.||. |.|.|:....|||||.|||||.|..|:|:||:||:||||.|:||
  Fly  1127 RRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLD 1191

Human  1289 GENRRILI-NTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYA 1352
            |..|.:|: ..|:.|||.|.....|..:|:|||||||:||..|.....|.|.|.|.|||.|....
  Fly  1192 GTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTISNELSYPFGITFTH 1256

Human  1353 DHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSH-LYGITAVYPYCP 1398
            |.||.|||....|..|:....:.|....|...|| :||:|.|..:||
  Fly  1257 DQFYWTDWTTKKVEIVDSLGARQTPIQPPFFGSHKMYGMTVVEQHCP 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NID2XP_005267462.1 NIDO 108..273 CDD:214712 48/171 (28%)
EGF_3 515..550 CDD:463759 18/34 (53%)
G2F 552..784 CDD:214774 69/234 (29%)
EGF_3 790..826 CDD:463759 13/40 (33%)
EGF_CA 828..870 CDD:214542 17/41 (41%)
EGF_3 879..917 CDD:463759 10/64 (16%)
EGF_3 923..956 CDD:463759 15/67 (22%)
TY 966..1032 CDD:238114 24/124 (19%)
TY 1046..1111 CDD:238114 14/75 (19%)
LY 1161..1199 CDD:214531 10/37 (27%)
LY 1205..1247 CDD:214531 20/42 (48%)
LY 1248..1292 CDD:214531 26/43 (60%)
LY 1293..1335 CDD:214531 18/42 (43%)
NdgNP_610575.1 NIDO 108..262 CDD:214712 49/175 (28%)
EGF_3 285..320 CDD:463759 18/34 (53%)
G2F 322..549 CDD:214774 70/240 (29%)
EGF_CA 591..622 CDD:429571 15/30 (50%)
EGF_3 797..828 CDD:463759 14/30 (47%)
EGF_3 836..873 CDD:463759 7/36 (19%)
EGF_3 963..995 CDD:463759 10/40 (25%)
EGF_3 1001..1036 CDD:463759 8/39 (21%)
NHL 1074..>1254 CDD:302697 85/180 (47%)
NHL repeat 1074..1112 CDD:271320 11/38 (29%)
LY 1107..1145 CDD:214531 17/37 (46%)
NHL repeat 1117..1156 CDD:271320 21/38 (55%)
LY 1152..1195 CDD:214531 26/42 (62%)
NHL repeat 1161..1202 CDD:271320 24/40 (60%)
NHL repeat 1210..1244 CDD:271320 15/33 (45%)

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