DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zim1 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_035899.4	Gene:	Zim1 / 22776	MGIID:	1341879	Length:	579	Species:	Mus musculus
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	146/510 - (28%)
Similarity:	216/510 - (42%)	Gaps:	103/510 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MKRSVSEV----KTKAPVNEASPSPSPDQ--------TANQLSEKKRRIPITSLPTWYKEPVIFK 53
            :|:|.:|:    |:.|.......||:.|.        :||||..|..:............|:...
  Fly    22 LKKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTAT 86

Mouse    54 DVAVYF-------SQKEWQLLE-PAQKDL---YKDVMLENYENLISVEYYIFKPKLITRLEQGVD 107
            ..:|..       .|:.::||: |.|:.:   .:|...:..:..:|.:
  Fly    87 TTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQQQFVSYQ----------------- 134

Mouse   108 LFAKENDVPGDPQQGEAGVSRSDTSA-----------GKKTGDNSTKAEIRKPDNSKTTSLEKQK 161
            |..:::......||.|:..:.:.|:|           |......:..:::|||..||
  Fly   135 LAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASK-------- 191

Mouse   162 AADQGRGSQSLRAEKTSKSDDRPSQNKEKCASTSTTEASKTS--IPGNKENESAIPGTSSGQTSA 224
                                  |....::|..|..::::.||  ...:|..:.::.|.|....:|
  Fly   192 ----------------------PQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAA 234

Mouse   225 ATTTPQSAPSEKPTSGKDVEGKPQTMRSSSTNPKRKP---ARQGKNHFKCKECGKTFNQTLHLVE 286
            ..:|   |..|...:|..| |.|:       :|..||   ...|.:.::|..|.|||.....|:.
  Fly   235 PVST---AAIELNDAGLPV-GIPK-------SPTIKPLANVAAGADPYQCNVCQKTFAVPARLIR 288

Mouse   287 HERIHTGEKPHKCDTCGKSFRHLSYFLTHYRIHTGVRPYKCKECGKAFNSSSTLNNHCRIHSGEK 351
            |.|.||||:|.:|:.|.|.|........|.||||..|||||..||:||..|..|:.|.|||:||:
  Fly   289 HYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGER 353

Mouse   352 PFKCDECGKTFKQSTKLTRHQRIHTGEKPYKCGE--CNKCFGRSSSLREHKRIHTGEKPYCCQVC 414
            |.||..|.|||.||.:|..|.|.|||||||||.|  |.|.|..|..|:.|.|.|||||||.|.:|
  Fly   354 PHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDIC 418

Mouse   415 GKTFRVNSHLSEHQRLHLKVKPYKCDKCGKHFRNSSYLTEHKQIHVPGARVDCPE 469
            .:.|..|..|..|:..|...|.|||..|.:.|:|.    :..:.|:.|...:.|:
  Fly   419 FRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNK----KEMEAHIKGHANEVPD 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zim1	NP_035899.4	KRAB	50..105	CDD:214630	8/65 (12%)
		PRK13335	137..>269	CDD:139494	25/136 (18%)
		COG5048	<226..427	CDD:227381	91/205 (44%)
		C2H2 Zn finger	271..291	CDD:275368	8/19 (42%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		C2H2 Zn finger	355..375	CDD:275368	10/19 (53%)
		C2H2 Zn finger	383..403	CDD:275368	9/21 (43%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		zf-C2H2	437..459	CDD:333835	6/21 (29%)
		C2H2 Zn finger	439..459	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..487	CDD:275368	1/3 (33%)
		C2H2 Zn finger	495..515	CDD:275368
		zf-C2H2	521..543	CDD:333835
		C2H2 Zn finger	523..543	CDD:275368
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/19 (21%)
		COG5048	<270..420	CDD:227381	77/149 (52%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	11/22 (50%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	14/24 (58%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..366	CDD:290200	13/21 (62%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	370..396	CDD:290200	16/25 (64%)
		C2H2 Zn finger	385..407	CDD:275368	9/21 (43%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	7/25 (28%)
		C2H2 Zn finger	443..463	CDD:275368	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910