DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfy1 and CG2889

DIOPT Version :9

Sequence 1:	NP_033596.3	Gene:	Zfy1 / 22767	MGIID:	99212	Length:	782	Species:	Mus musculus
Sequence 2:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	151/743 - (20%)
Similarity:	251/743 - (33%)	Gaps:	236/743 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 NPGSVIIQDVIENVLIEDVHCSHILEETDISDNVIIPEQVLNLGTAEEVSLAQFLIPDILTSGIT 120
            :|||.:                 .|.||   |:.:...:::.:       :|:||..:||.....
  Fly    11 SPGSAV-----------------FLFET---DDTLAETRLVKM-------IAKFLQLEILPDDGI 48

Mouse   121 STSLTMPEHVLMSEAIHVSDVGHFEQVIHDSLVETEVITDPITADTSDILVADCVSEAVLDSSGM 185
            |||      |......|:.|...|.|::...  :..:..:.:|.|      .||.  |:..:.|:
  Fly    49 STS------VCTECCEHLEDFNGFWQLVEQK--QCSLKKEFLTVD------VDCA--AMKWTGGV 97

Mouse   186 PLEQQDNDKINCEDYLMMSLDEPSK-ADLEGSSEVTMNAESGTDSSKLDEASPEVI--------K 241
            .::      :|.::..:.:.|...| .||...|.:....:...||.::.|...|.:        |
  Fly    98 DVD------VNIDELPLAAGDMDEKPLDLHNLSLLGSVLDVNVDSVEVREPIKEQLPCEEEEDEK 156

Mouse   242 VCILKADSEVDELGETIHAVESETKNGNEAEVTDQSTSIRVPRVNIYMSASDSQKEEEDTEVIVG 306
            .|:..:||                    |.|||:              ...:|:.:..|.|.:|
  Fly   157 PCLQASDS--------------------EPEVTE--------------GQPESESDSSDDEPLV- 186

Mouse   307 DEDAGGTAADTPEHEQQMDVSEIKAAFLPIAWTAAYDNNSDEIEDQNVTASALLNQDESGGLDRV 371
                                 .:|:...|...|:|..:     :||...:   |.|:.:..||..
  Fly   187 ---------------------RLKSKMKPKRKTSARSS-----KDQGPIS---LQQELADLLDDG 222

Mouse   372 PKQKSKKKKRPESKQYQSAIFVAPDGQTLRVYPCMFCGKKFKTKRFLKRHTKNHPEYLANKKYHC 436
            .|::.:|               |||.:|                                    .
  Fly   223 GKRRRRK---------------APDQRT------------------------------------T 236

Mouse   437 TECDYSTNKKISLHNHMESHKLTIKTEKTTECDDCRKNLSHAGTLCTHKTMHTEKGVNKTCKCKF 501
            ||             ..||....:...|...|...:...|:...:.::          .:..|..
  Fly   237 TE-------------SQESELQAVLERKPKGCSRAQLAKSYEKAIASY----------MSASCDL 278

Mouse   502 CDYETAEQTLLNHHLLVVHRKKFPHICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADS 566
            |::.....:.|..|.|.||::::...|  |||.|...|.|..|||.|...|.:.|..|: ||.:|
  Fly   279 CEFSAPYLSELKTHFLEVHQREYYIKC--CGKVFTRASKLMDHIRKHINPKLFTCTICK-KSLNS 340

Mouse   567 SN-LKTHIKSKHS------KEIPLKCGICLLTFSDNKEAQQHAVLHQ-ESRTHQCSHCNHKSSNS 623
            .: |.|||::.|:      |.:...|..|..|||..:....|...|. :...|.|..|....:|.
  Fly   341 QDYLATHIETVHNKVAQIGKVLKFPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANV 405

Mouse   624 SDLKRHIISVHTKAYPHKCDMCSKGFHRPSELKKHVATHK--------------------SKKMH 668
            ..|:|||.|:|...:.|.||:|.|.|......::|:..|:                    |.::|
  Fly   406 HRLRRHIQSIHEDLHRHVCDICGKKFKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLH 470

Mouse   669 Q---------CRHCDFNSPDPFLLSHHILSAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRKV 724
            :         |.||.........|..|:..||......:|..|:|.|:||..|..||..|:..::
  Fly   471 RFTHDSTDTVCPHCGKTCTSRTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQL 535

Mouse   725 YQCEYCEYSTKDASGFKRHVISIHTKDY 752
            |.|.:|....:..|....|:...|..::
  Fly   536 YNCPHCPKECRSRSNMYVHIKQRHADEW 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfy1	NP_033596.3	Zfx_Zfy_act	68..388	CDD:282547	57/328 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..386		6/25 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		2/9 (22%)
		C2H2 Zn finger	405..425	CDD:275370	0/19 (0%)
		C2H2 Zn finger	436..456	CDD:275370	3/19 (16%)
		C2H2 Zn finger	468..488	CDD:275368	2/19 (11%)
		C2H2 Zn finger	499..520	CDD:275368	5/20 (25%)
		COG5048	<513..687	CDD:227381	58/210 (28%)
		zf-C2H2	526..548	CDD:278523	10/21 (48%)
		C2H2 Zn finger	528..548	CDD:275368	10/19 (53%)
		zf-H2C2_2	540..562	CDD:290200	8/21 (38%)
		C2H2 Zn finger	556..577	CDD:275368	9/21 (43%)
		C2H2 Zn finger	585..605	CDD:275368	6/19 (32%)
		C2H2 Zn finger	613..634	CDD:275368	8/20 (40%)
		C2H2 Zn finger	642..691	CDD:275368	14/77 (18%)
		C2H2 Zn finger	699..719	CDD:275368	9/19 (47%)
		zf-H2C2_2	711..735	CDD:290200	7/23 (30%)
		C2H2 Zn finger	727..748	CDD:275368	4/20 (20%)
		C2H2 Zn finger	756..776	CDD:275368
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	20/102 (20%)
		C2H2 Zn finger	276..297	CDD:275368	5/20 (25%)
		C2H2 Zn finger	306..323	CDD:275368	9/16 (56%)
		C2H2 Zn finger	331..352	CDD:275368	9/21 (43%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..416	CDD:275368	8/20 (40%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..502	CDD:275368	5/20 (25%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..556	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000