DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc2a6 and CG33282

DIOPT Version :9

Sequence 1:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus
Sequence 2:	NP_001097067.1	Gene:	CG33282 / 2768939	FlyBaseID:	FBgn0053282	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	114/468 - (24%)
Similarity:	215/468 - (45%)	Gaps:	42/468 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse    33 KNRRVFLATFAAVLGNFSFGYALVYTSPVIPELKLSSDPA-LHLDKIQASWFGSVFTLGAAAGGL 96
            |.|...|||....:..|..|..:.:.||.:.:::.:..|. ..::..|.||.||:..|.:..|.|
  Fly    13 KTRYQLLATVIVNIITFGHGVGVGWLSPTLTKIQTADSPLDFEVNLAQISWLGSMLGLDSLCGNL 77

Mouse    97 SAMLLNDLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGRMLTGFAGGLTAACIPVYVSEIAP 161
            :..:|.:..|||..:...|.|.|..:.::..|..::.|...|.|.||.||.....:|:::||:|.
  Fly    78 TIAMLIERAGRKFCLYLMAGPYACIWILIYCASNVYYLYAARFLCGFTGGAGYLVVPIFISEVAD 142

Mouse   162 PDVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLIMILLLSF------MPNSPRFL 220
            .::||||.:...|....|.|:.|.|...|.:..:      |.|.:||.:::      :|.:..:|
  Fly   143 SNIRGALTSMVMLSVDLGILAGYILSTYLAYHVV------PFLAIILPVAYFIANIMLPETAPYL 201

Mouse   221 LSKSRDEEALQALTWLRADSEVHWE------FEQIQDNVRRQSSRVSWAEAREPRVYRPVL---- 275
            |.||:...|..:..:.|.......|      ||:::..|..|.:|.:...:.:....:|.|
  Fly   202 LKKSQLAAAENSFRYYRNQRSAICEQTSKVNFEELRTAVLSQQTRNATPLSYKDLTTKPALKGFA 266

Mouse   276 IAVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAAVTMDLAGRKVLL 340
            .::::....|.:|:...:.|:..||..:..|:.......|:|.|:::.|..:.:.:|:.||:||:
  Fly   267 ASIVLSLGYQFSGVFSFINYMSDIFKASGSVVDVNTATIIIGLVQIVGVYTSTILVDIVGRRVLM 331

Mouse   341 YVSASVMFAANLTLGLYVQFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLATMLFIMGYAMGWG- 404
            .:|...:....:..|.:...          .:|..|.|  ||:|.|:     ::.|:.|....|
  Fly   332 LISTMGVGIGCIAFGCFTYL----------AKIYDLSD--FNWLPLV-----LMIIICYVANIGL 379

Mouse   405 -PITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFFFSAICLLSLLF 468
             .|.:|::.|:.|::.|.:|:.|.|:...|..|.....|.|.::.:|:....:|.:|..||:..:
  Fly   380 IGIFFLVLVELFPVKIRSLATSLSVIFLSLLVFGTLKLFPLMLHYWGISFTMWFSAASALLTFFY 444

Mouse   469 TGCCVPETRGRSL 481
            ....:.||:|:|:
  Fly   445 FWLFLQETKGKSM 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	112/463 (24%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		2/5 (40%)
CG33282	NP_001097067.1	MFS	21..448	CDD:119392	106/449 (24%)
CG33282	NP_001097067.1	MFS_1	53..409	CDD:284993	91/378 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950