Protein Alignment Zfpm2 and ush

DIOPT Version :10

• Sequence 1: NP_035896.1
• Gene: Zfpm2 / 22762
• MGIID: 1334444
• Length: 1151
• Species: Mus musculus
• Sequence 2: NP_001259829.1
• Gene: ush / 33225
• FlyBaseID: FBgn0003963
• Length: 1212
• Species: Drosophila melanogaster
• Alignment Length: 1420
• Identity: 259/1420 - (18%)
• Similarity: 406/1420 - (28%)
• Gaps: 590/1420 - (41%)

Mouse     6 QSKPRQIKRPLEDAIDDEEEECPVEEAEVISKGDFPLEGSFPAGFEPENLSCEDVEFFCNKGDDE 70
            :.|.:|::..|||.::|..                          :|:|             ::.
  Fly    34 EQKQQQMEDQLEDQLNDSR--------------------------DPQN-------------NNN 59

Mouse    71 GIQEPAESDGDSHSDKPGQPGVETDDWDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDL 135
            .|.:.|:.|.:....:...|..:.|    .||.|:.|....::...:|:||.
  Fly    60 NIDDDADEDAEFEEPEKANPQQDQD----LGETEMEQEHDLQQEDLQQELPA------------- 107

Mouse   136 NNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYSKGGQLWCTTTKAISEGEELVAFVV 200
              ||..|..:.|......|| |........|...:.|...|.     |.|.|  .....|.|.:.
  Fly   108 --NSPSTPPRSPSSPQLIPK-LEQPATPPSEPEASPCPSPSP-----CPTPK--YPKVRLNALLA 162

Mouse   201 DFDSRLQAASHMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNL 265
            ...:....|..:||.:    :|||....|:.........:...::....|.|..|||.:.|...|
  Fly   163 SDPALKPDAKELTLPD----SRLLAPPPLVKPDTQAQPEVAEPLLKPARFMCLPCGIAFSSPSTL 223

Mouse   266 QAHLMYYCSGRQREAAPVSEENEDNSHQVSSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLP 330
            :||..||||.|.::   ..|...|.|....|       ..:..:|..|       :|...|   |
  Fly   224 EAHQAYYCSHRIKD---TDEAGSDKSGAGGS-------GATAGDAAGL-------TGGSTE---P 268

Mouse   331 P------GASLKCTVCSYTADSVINFHQHLFSHLTQAAF-------------------------- 363
            |      |....||.|||:||..::.::|:..|.|..|.
  Fly   269 PAKMARTGKQYGCTQCSYSADKKVSLNRHMRMHQTSPAAPTLAGLPSLLQNGIAPPGVTPNPMED 333

Mouse   364 --------RCNHCHFGFQTQRELLQHQELHV----PSGKLPRESDMEHSP--------------- 401
                    .|:||...|...:....|::.:.    |.|:|..:.|.  ||
  Fly   334 SSSQQTDRYCSHCDIRFNNIKTYRAHKQHYCSSRRPEGQLTPKPDA--SPGAGSGPGSAGGSIGV 396

Mouse   402 ---SGTEDSLQP---------------ATDLLARSDLSQSQKA---------------------- 426
               :.|...|.|               |....|.:.|..:..:
  Fly   397 SAQAATPGKLSPQARNKTPTPAMVAVAAAAAAAAASLQATPHSHPPFLALPTHPIIIVPCSLIRA 461

Mouse   427 -------MPTKDASSDTELDKC---------EKKTQLFLTNQRPEIQPAANKQNFSYTKIKSEPS 475
                   :||.::........|         ...|.|......|| :|:|.......|:.||.|.
  Fly   462 ASFIPGPLPTPNSGIVNPETTCFTVDNGTIKPLATALVGATLEPE-RPSAPSSAAEATEAKSSPP 525

Mouse   476 SPR----------------LASSPVQPN-----------------------IG------------ 489
            .|:                |..||:..|                       :|
  Fly   526 EPKRKEAGLTRESAPLDLSLRRSPITLNSLSLRQRQLRNALLDVEEVLLAGVGTGKENVETPRGG 590

Mouse   490 -----------PSFPVGPFLS--------------------------QFAFPQDI---TMVPQ-- 512
                       ||.|..|.:|                          ..|.|..:   :|:|.
  Fly   591 GSVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGAGSASSMSPPGLNVAVPHLLDMRSMLPADF 655

Mouse   513 --ASEILAKMSELVHRRL-----------RHGSSSYPPV------------------------IY 540
              :..:|||.:..:..:|           ..|::::||.                        ||
  Fly   656 GLSESLLAKTNPELALKLAAAAAAAAVAGSSGAAAFPPASLPAQTSSGNPGSGGSAGGAQQPQIY 720

Mouse   541 SPLMPKGAT-CFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEAVSPNTGQTSI 604
               :.||.: |.||||.|...:|||.||:||||:|.|:.|...:..|       ||||:
  Fly   721 ---VKKGVSKCMECNIVFCKYENYLAHKQHYCSARSQEGASEVDVKS-------AVSPS------ 769

Mouse   605 NLLNPAAHSSDPENPLLQTSCINSSTVLDLIGPNGKG-HEKDFSTQVKKLPTSNSSDDKINGKPV 668
                                         :.|..|.| ...:.::.|:..|.:.
  Fly   770 -----------------------------IAGAGGLGAGAAEAASSVETTPVAY----------- 794

Mouse   669 DVKNPSGPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYC----------ATRHDP-----PL 718
                            .:..|.||.|.::..:....|:.|||          ||..||     |.
  Fly   795 ----------------QQLICAACGIKYTSLDNLRAHQNYYCPKGGAVAAPAATPTDPGQLGMPK 843

Mouse   719 KRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVAN-LSNPCSSTQEPTEGLGE 782
            ::..              |.:.::|:.||    .||       .||| |:.|..:.|..|..|.:
  Fly   844 EKCG--------------KCKTLHEIGLP----CPP-------PVANPLAAPTVNPQPATNSLNK 883

Mouse   783 CYHPRCDIFPGIVS-------KHLETSLAMNKCVPVPKCDTTHSNVSCLEMDVPIDLSKKCLSQS 840
            |  |.|    |:||       ||:|                .|..|..
  Fly   884 C--PVC----GVVSPTAALAKKHME----------------MHGTVKA----------------- 909

Mouse   841 ERTTASPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERSSP 905
                         :.|::|:...|.:.....|      :..|.......::.:::.....|..:.
  Fly   910 -------------YRCSICQYKGNTLRGMRTH------IRTHFDKKTSDVNEELYMTCIFEEDAS 955

Mouse   906 EVSFERNMIKCEKNGNPKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENKHLFLPQCLYPG 970
            .:|.|             ..:|.|      .:|..|.......:|:.            .|.|..
  Fly   956 ALSQE-------------LVTPTG------ASTTTGHDSMDHPSQMF------------NCDYCN 989

Mouse   971 AIKKTKG-----ADQLSPYYGIKPSDYIASSLVIHNTDVEQSTN-TENESPKGQASSNGCAVPKK 1029
            .:...||     ...:.|:..|.     :.|:.....|.:.::| |.|:......|:........
  Fly   990 YVSTYKGNVLRHMKLMHPHVAIN-----SPSISPDTRDQDVTSNPTTNQHSNSDVSNGEAPSFHI 1049

Mouse  1030 DSLPLLPKNRGMVIVNGGLKQDERPTANPQQENISQNTQHEDGHKSPSWISENPLAANENVSPG- 1093
            .|.||                |..||.|...||  .|:.....|     |...|:....:.:||
  Fly  1050 KSEPL----------------DPPPTVNLVHEN--NNSPIATPH-----IKAEPIEVGADAAPGG 1091

Mouse  1094 -IPCAEEQL---SSIAKGVNGASQAPSSGKYCRLCDIQFNNLSNFITHKKFYCSS 1144
             :|.....|   ||:|.....|::...  |||..|||.||.:..::.||:|||.:
  Fly  1092 LVPPMTSPLGNSSSVAAAAAAAAEVMK--KYCSTCDISFNYVKTYLAHKQFYCKN 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zfpm2	NP_035896.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		6/46 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..101		5/35 (14%)
		PR-SET_ZFPM2	97..207	CDD:380993	22/109 (20%)
		C2H2 Zn finger	301..320	CDD:275368	2/18 (11%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..486		28/183 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..684		4/47 (9%)
		Nuclear localization signal	736..740		1/3 (33%)
		Interaction with CTBP2. /evidence=ECO:0000305	829..835		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1004..1035		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1049..1093		10/43 (23%)
ush	NP_001259829.1	zf-H2C2_5	279..301	CDD:404746	8/21 (38%)
		C2H2 Zn finger	884..904	CDD:275370	9/41 (22%)
		C2H2 Zn finger	912..932	CDD:275370	4/25 (16%)
		zf-H2C2_5	983..1003	CDD:404746	4/31 (13%)