DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp93 and M1BP

DIOPT Version :9

Sequence 1:	NP_001347156.1	Gene:	Zfp93 / 22755	MGIID:	107611	Length:	663	Species:	Mus musculus
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	158	Identity:	62/158 - (39%)
Similarity:	84/158 - (53%)	Gaps:	9/158 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse   289 SVPIQPSVH--PGRKR-----YWCHECGKGFRQSSALQTHQRVHTGEKPYRCDSCGKGFSRSSDL 346
            |:|.:|.|.  ..|:|     |.|.:||...:...|.:.|.|.|.|:|.:.|:.|...|..:|:|
  Fly   230 SLPPKPKVRSDDARRRGTGGVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSEL 294

Mouse   347 NIHRRVHTGEKPYKCEVCGKGFTQWAHLQAHERIHTGEKPYKCGDCGKRFSCSSNLHTHQRVHTE 411
            ..|.|.||||:|:.|:.||:.||.:.....|||.||.|:||.||.|||.|:....|..|..:|:.
  Fly   295 KRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSG 359

Mouse   412 EKPYECNECGKRFSLSGNLDIHQR--VH 437
            |:.|.|..|.|.|.|..:|..|.|  ||
  Fly   360 ERAYRCELCDKSFMLPTHLSTHFRSGVH 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp93	NP_001347156.1	KRAB	25..66	CDD:307490
		COG5048	275..>613	CDD:227381	62/158 (39%)
		C2H2 Zn finger	305..325	CDD:275368	6/19 (32%)
		C2H2 Zn finger	333..353	CDD:275368	7/19 (37%)
		C2H2 Zn finger	361..381	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..409	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..437	CDD:275368	8/21 (38%)
		C2H2 Zn finger	445..465	CDD:275368
		C2H2 Zn finger	473..493	CDD:275368
		C2H2 Zn finger	501..521	CDD:275368
		C2H2 Zn finger	529..549	CDD:275368
		C2H2 Zn finger	557..577	CDD:275368
		C2H2 Zn finger	585..605	CDD:275368
		C2H2 Zn finger	613..633	CDD:275368
		C2H2 Zn finger	641..661	CDD:275368
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		COG5048	276..>331	CDD:227381	22/54 (41%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		zf-H2C2_2	324..346	CDD:290200	14/21 (67%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:290200	8/21 (38%)
		C2H2 Zn finger	365..383	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910