DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp93 and CG11247

DIOPT Version :9

Sequence 1:	NP_001347156.1	Gene:	Zfp93 / 22755	MGIID:	107611	Length:	663	Species:	Mus musculus
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	117/346 - (33%)
Similarity:	173/346 - (50%)	Gaps:	17/346 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse   313 RQSSALQTHQRVHTGEKPYRCDSCGKGFSRSSDL---NIHRRVHTGE----KPYKCEVCGKGFTQ 370
            |:.|:|.:.:.....|:.   |..|:..|:..|.   .:.:....||    |.:.|..|.|.|..
  Fly    43 RRKSSLASLRDACVDEEE---DDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGG 104

Mouse   371 WAHLQAHERIHTGEKPYKCGDCGKRFSCSSNLHTH-QRVHTEEKPYECNECGKRFSLSGNLDIHQ 434
            ...||.|..||:.|:|:||.||||.:..:.||..| ...|...|.:.|::|.|.|:|...|.:|.
  Fly   105 KTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHM 169

Mouse   435 RVHTGEKPYKCEECGKGFSSASSFQSHQRVH--TGEKPFHCSVCGKNFSRSSHFLDHQRIHTGEK 497
            |:|:|||||.|:.|.|.|:.....|.|...|  |..:.|:|:.|..:||.:::...|...|....
  Fly   170 RLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGM 234

Mouse   498 PYRCEVCGKRFPWSLSLHSH-QSVHTGKKPYKCGECGKGFSHASSLQAHHSVHTGEKPFKCNVCQ 561
            .:||.:|..:|...|:|.:| ...|.....::|..|.|.......|..|...||..|...|.||.
  Fly   235 EHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCN 299

Mouse   562 KQFSKTSNLQAHQRVHTGEKPYKCDTCGKAFSQKSSLQVHQRIHTGEKPFKCEECGKEFRWS--V 624
            ..|::.|....|.|:||||:||:|..|.:.|:..|.|::|.|.|||||||:|:.|..|..:|  .
  Fly   300 TYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLA 364

Mouse   625 GLSSH-QRVHTGEKPYTCQQC 644
            .|.:| :::|..:|||.|:.|
  Fly   365 HLKNHMKKIHKQQKPYMCEGC 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp93	NP_001347156.1	KRAB	25..66	CDD:307490
		COG5048	275..>613	CDD:227381	105/310 (34%)
		C2H2 Zn finger	305..325	CDD:275368	3/11 (27%)
		C2H2 Zn finger	333..353	CDD:275368	4/22 (18%)
		C2H2 Zn finger	361..381	CDD:275368	7/19 (37%)
		C2H2 Zn finger	389..409	CDD:275368	8/20 (40%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	473..493	CDD:275368	5/19 (26%)
		C2H2 Zn finger	501..521	CDD:275368	6/20 (30%)
		C2H2 Zn finger	529..549	CDD:275368	5/19 (26%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
		C2H2 Zn finger	585..605	CDD:275368	7/19 (37%)
		C2H2 Zn finger	613..633	CDD:275368	6/22 (27%)
		C2H2 Zn finger	641..661	CDD:275368	2/4 (50%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	13/24 (54%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000