DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zfp85 and CTCF

DIOPT Version :9

Sequence 1:	XP_036013928.1	Gene:	Zfp85 / 22746	MGIID:	107767	Length:	481	Species:	Mus musculus
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	131/425 - (30%)
Similarity:	181/425 - (42%)	Gaps:	75/425 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 NMKDLLSFTDVAI--DFSADECECLDSAQWNLYKEVMLENYS----NLVFLGSKPHKCKECGKAF 98
            |..::..|.|.|.  |.:||:.: :|....|  |||.|:..|    |....|.| :.|..|....
  Fly   243 NEAEVYEFEDNATTEDENADKKD-VDFVLSN--KEVKLKTASSTSQNSNASGHK-YSCPHCPYTA 303

Mouse    99 DRNSVLIQHQRIHTGERSYKCEECGKSFNYSSSFKQHQRIHTGEKPYKCEVCGKAFNCSSYLGKH 163
            .:..::.:|.|.|..|.|:||..|.:||..:...:.|...|.|.||:||::|..||..|..|.:|
  Fly   304 SKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRH 368

Mouse   164 QRIHTGEKRYKCEECGKPFTNCSGLIVHRRVHTGEKPYKCEECGKAFSVGTTLSNHQRIHTGEKP 228
                   .|||                    ||.|||:||.||..|....|.|..|...||||:|
  Fly   369 -------TRYK--------------------HTKEKPHKCTECTYASVELTKLRRHMTCHTGERP 406

Mouse   229 YKCEECGMAFNVRFLLSKHQQTHTGEKPYKCKECGKAFNCSSSLHQHQQIHR--GEKLYKCDDCG 291
            |:|..|..|....|.|.:|...|||||.|:|..|...|..|:||..|:.||.  .:.:::|:.|
  Fly   407 YQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYC- 470

Mouse   292 QAFSCSSYLYKHRRIHTGMKPSKCKECGKTFYCSVNLIYHQRIHTGEKPYKCNECGKAFSIYSRF 356
                                |:   .||:.....|::   :.:||.:.|..|..||:......::
  Fly   471 --------------------PT---TCGRKADLRVHI---KHMHTSDVPMTCRRCGQQLPDRYQY 509

Mouse   357 MKHQRIHSGEKPYKCKECEKAFNNCYNLIQHQRIHTGEKPYKCKDCGKAFHYTSSLAQH-ERIHT 420
            ..|.:.|.|||.|.||.|..|.....:|..|..||..|||:.|..|.:||.....|.:| ..:|.
  Fly   510 KLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHN 574

Mouse   421 --------GEKPYKCEECGKAFNSSSNLKNHWRLH 447
                    .||.:||..|.:.|....||..|...|
  Fly   575 EEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp85	XP_036013928.1	KRAB	45..>90	CDD:214630	16/50 (32%)
		C2H2 Zn finger	91..111	CDD:275368	4/19 (21%)
		COG5048	115..480	CDD:227381	108/344 (31%)
		C2H2 Zn finger	119..139	CDD:275368	5/19 (26%)
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		C2H2 Zn finger	175..195	CDD:275368	0/19 (0%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	2/19 (11%)
		C2H2 Zn finger	315..335	CDD:275368	3/19 (16%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	6/20 (30%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	321..>621	CDD:227381	108/343 (31%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	10/47 (21%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	6/44 (14%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000