DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FHL1 and pk

DIOPT Version :9

Sequence 1:	XP_006724806.1	Gene:	FHL1 / 2273	HGNCID:	3702	Length:	339	Species:	Homo sapiens
Sequence 2:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster

Alignment Length:	224	Identity:	61/224 - (27%)
Similarity:	95/224 - (42%)	Gaps:	27/224 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    74 NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
            |..||..||.|:.|...|.:..:..:|.::.|.:.......|:|..|.:.|:| |:..|.:|..|
  Fly   646 NASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILA-DECTEAEGRAW 709

Human   139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAI--TSGGITYQDQPWHA-- 199
            |.:.|.|..|.:.:|...:..:....||:.|.:..||::|..|.:||  ..|.:::..|.|||
  Fly   710 HMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATD 774

Human   200 DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYKNFVAKKCAGCKNPIT-----GKRTVSRVSHPVS 258
            :||.|.||...|.|:.|.......|| :.|.|.          .|.|     |....:..:.|..
  Fly   775 ECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKG----------EPPTPSDSSGTGMYTTPTPPTQ 829

Human   259 KARKPPVCHGKRLPL-TLFPSANLRGRHP 286
            :.|..|     :.|| ...||::.....|
  Fly   830 RVRPHP-----QAPLPARIPSSHASSSPP 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FHL1	XP_006724806.1	LIM	<21..49	CDD:413332
		LIM1_FHL1	56..109	CDD:188730	10/34 (29%)
		LIM2_FHL1	117..174	CDD:188808	16/56 (29%)
		LIM3_FHL1	178..230	CDD:188813	20/56 (36%)
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602
		LIM1_Prickle	624..682	CDD:188799	10/35 (29%)
		LIM2_Prickle	687..742	CDD:188802	17/55 (31%)
		LIM3_Prickle	747..805	CDD:188804	19/57 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810