DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp60 and CG6689

DIOPT Version :9

Sequence 1:	NP_033586.2	Gene:	Zfp60 / 22718	MGIID:	99207	Length:	704	Species:	Mus musculus
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	144/619 - (23%)
Similarity:	215/619 - (34%)	Gaps:	161/619 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse   175 CKDCGKCFGCKSNLHQHESIHTGEKPYECKD--------CGKT-----FRLPQMLSRHQKSHSDE 226
            |::...| ..|.|..|.:.:.....| :|.|        ||.|     .:.|.:...|.|....|
  Fly     8 CRNFSDC-RSKRNAAQQQRLGFFRFP-KCPDTFKAWLAFCGYTEESLKLKNPCICIEHFKDEDIE 70

Mouse   227 --RPFECNICGKSFHLPTLLQ-YHKNIHTG-----------------LKPFECEECGKSFNRIST 271
              ..||..:..|....|..:. .:|:..:|                 :.....||..|..:..:|
  Fly    71 GSLKFEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAKLIHPEAT 135

Mouse   272 LFQH------RTIHAGMKP----------YKCNVCGKAFN-----------RRSNLLQHQKI--- 306
            .|:.      .|:...:.|          .||..|...|.           ..|.||.|.::
  Fly   136 SFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISG 200

Mouse   307 ----HSEDRP-FHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNGSYLLRHYDTHTNE 366
                |..|.| ..|..|..|....... |...|.||.|..:.|.     |.....:.    ..||
  Fly   201 VWISHKPDEPRLMCPACKSALDQAIDF-REMCISTELKLSQAKP-----STDEVQIE----AENE 255

Mouse   367 KPFECNICGKAFRLHLYLSEHQKTHTDE------------------------------------- 394
            .|...:        |..:|:.:.|:.:|
  Fly   256 NPISSD--------HDLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPL 312

Mouse   395 ------KPFKCKLCESAFRRKYQLSEHQRIHTDVKPYQCKDCGKFFRRRS---------NFTEHQ 444
                  |.||..|.:...:.|.:|.:...|.:..|..: |..|:...:||         |.....
  Fly   313 SVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKE-KAAGEQKPKRSANPKTKEERNLIRRA 376

Mouse   445 SIHTGKKPFECKDCGKVFR----LNIHLIRHQRFHSDEKPFECKECGKAFHFSSQLNNH-KTSHT 504
            .:......|.|..||:.||    |.||::||.|    .|.::|.||.|.|:.:...|.| :..|.
  Fly   377 QLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTR----TKNYQCTECPKTFYDAYMRNMHIRIRHR 437

Mouse   505 GQTPFECKECGKSFKRVSSLVEHRI-IHSGVKPYKCNACGRAFNRRSNLMQHEKIHSDERPFECK 568
            |:|||.|..|.::|....:..:|.. :|        ||..|...:|.|.....|.....| ::||
  Fly   438 GETPFACGFCSETFAYPGARQKHESEVH--------NAAPRLIVKRINPKPMPKPRESVR-YQCK 493

Mouse   569 DCGKAFTVLAQLTRHQTIHNGKKSYECEQCGSAFRLPYQLTQHQRIHYDVKPFQCKECGKGFVRS 633
            .|.|.:.....|..|...|....:|:|::|..::..|.:|.:|:..| :.:|.||..|.|||.:.
  Fly   494 LCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTH-EKRPLQCDVCLKGFYQR 557

Mouse   634 TGLRIHERIHTGEKPFQCKECGEAFQYHYQFLGH 667
            |.||.||.|||||:|:.|:.|...|:|.|....|
  Fly   558 TRLREHELIHTGERPYWCEVCNVNFRYKYNMKSH 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp60	NP_033586.2	KRAB	14..75	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		C2H2 Zn finger	203..223	CDD:275368	8/32 (25%)
		COG5048	212..640	CDD:227381	119/540 (22%)
		zf-H2C2_2	215..239	CDD:290200	6/25 (24%)
		C2H2 Zn finger	231..251	CDD:275368	3/20 (15%)
		zf-H2C2_2	244..268	CDD:290200	5/41 (12%)
		C2H2 Zn finger	259..279	CDD:275368	6/25 (24%)
		C2H2 Zn finger	287..307	CDD:275368	7/37 (19%)
		zf-H2C2_2	299..323	CDD:290200	9/31 (29%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		C2H2 Zn finger	343..363	CDD:275368	2/19 (11%)
		zf-H2C2_2	355..378	CDD:290200	3/22 (14%)
		C2H2 Zn finger	371..391	CDD:275368	2/19 (11%)
		C2H2 Zn finger	399..419	CDD:275368	3/19 (16%)
		C2H2 Zn finger	427..447	CDD:275368	5/28 (18%)
		C2H2 Zn finger	455..475	CDD:275368	11/23 (48%)
		zf-H2C2_2	467..491	CDD:290200	9/23 (39%)
		C2H2 Zn finger	483..503	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..531	CDD:275368	4/20 (20%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	551..575	CDD:290200	7/23 (30%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		C2H2 Zn finger	623..643	CDD:275368	10/19 (53%)
		zf-H2C2_2	636..658	CDD:290200	12/21 (57%)
		C2H2 Zn finger	651..671	CDD:275368	6/17 (35%)
		C2H2 Zn finger	679..699	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206	19/89 (21%)
		zf-AD	167..240	CDD:214871	18/73 (25%)
		zf-C2H2	385..407	CDD:278523	9/21 (43%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	11/26 (42%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	10/19 (53%)
		zf-met	574..597	CDD:289631	6/18 (33%)
		C2H2 Zn finger	575..591	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100