DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp52 and Meics

DIOPT Version :9

Sequence 1:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	172/615 - (27%)
Similarity:	265/615 - (43%)	Gaps:	88/615 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    92 RSDTTEASNNYRCCNEKDA------SVDSSNADRHKSMHIGEEDTCQSKDCEKSFNLCSNIRQYQ 150
            ||.......|.|.|.|..:      |.:.|:....:.::....:.|:.|..|....:|.......
  Fly    11 RSVDASMGKNCRACAEHSSILVDLFSKEISDPPIWEMLNSILPEICRVKRDEMPQKICPTCLVAA 75

Mouse   151 RLNTEKKEHKQDEHDDHFSSLYSLMQETVDMEEKPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYK 215
            : |.....||.::....||.|..|     |.........|||:  .|.:.| |...|...|.|..
  Fly    76 Q-NAFHFRHKCEQSFQFFSQLLQL-----DKSNSNLSRSHCRR--GTMNPL-IPFEIVGCEDPLD 131

Mouse   216 CNICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLL----VQLSALKSHQR---RHTGEKPYKCQ 273
            .|:.....|: ..:|||....|..|....:|...|.    :.::.:|:...   :.|.|..:. :
  Fly   132 TNVTKLDANR-PDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTEDEVSIQETFEDAFD-E 194

Mouse   274 QCDRSFAHCA---SLRWHQKIHSPEIHYE--------------------CKECGKSCFELSHLKR 315
            :.|.:.....   |.:|  .:.|.|...|                    |.|||.|......|.|
  Fly   195 ENDNNNTDSEREDSDQW--TVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALAR 257

Mouse   316 HCRIH----TAEKPYRYEVCDTSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLRTYQRVH 376
            |...|    ..:||:..:.|......|:.|.||                            :|.|
  Fly   258 HVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTH----------------------------RRRH 294

Mouse   377 TGKRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKCKDCDKSFLRISSVRIRQKIHAGERRYRCK 441
            ||:||::|..|.|.:|....|:.|...|..||..||..|||:|....::|...:.|.|||.|:|.
  Fly   295 TGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCP 359

Mouse   442 ECGRSFTWFSNLRVHQRVHTGERPYRCKECGKSFTTGSNLRVHQKIHTGEKPYKCKDCDISFLWI 506
            :|.::|...|.|::|.|:|..|||::|:.|||.|....:|..|.::|.|::.:||.|||.||...
  Fly   360 DCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEK 424

Mouse   507 SNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYKCKDCDISFMWISSLRRHQKI 571
            ||:..||:.|:|.||:||:||.::|:...:|:.|.:||||||.|||..|...|....||.:|...
  Fly   425 SNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLW 489

Mouse   572 H--TGEKPYKCRGCEKSFTQCSTLRDHQKIHTG-EKP---YKCKDCGISFLWISSLRRHQKIHTG 630
            |  ..::|:||..|.|::....:||.|:|.|.. ::|   ::|..|.:.|....:|.:|...|.
  Fly   490 HVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK- 553

Mouse   631 EKPYKCKDCDISFLWISNLRTHQKIHTGEK 660
            .:|:.|..|...|....:|:.|.::|..:|
  Fly   554 IRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587
		C2H2 Zn finger	134..153	CDD:275368	3/18 (17%)
		COG5048	184..615	CDD:227381	140/470 (30%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..264	CDD:275368	10/54 (19%)
		C2H2 Zn finger	244..259	CDD:275368	2/18 (11%)
		C2H2 Zn finger	272..292	CDD:275368	3/22 (14%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..348	CDD:275368	5/18 (28%)
		C2H2 Zn finger	357..376	CDD:275368	1/18 (6%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	496..516	CDD:275368	10/19 (53%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	5/19 (26%)
		zf-H2C2_2	620..643	CDD:372612	6/22 (27%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:372612	4/13 (31%)
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_5	690..714	CDD:372805
		C2H2 Zn finger	692..712	CDD:275368
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	14/74 (19%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	274..294	CDD:275368	6/47 (13%)
		zf-H2C2_2	287..311	CDD:290200	12/51 (24%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	8/23 (35%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	65/188 (35%)
		zf-C2H2	412..434	CDD:278523	11/21 (52%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	5/15 (33%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000