DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zfp40 and Meics

DIOPT Version :9

Sequence 1:	NP_001344626.1	Gene:	Zfp40 / 22700	MGIID:	99185	Length:	796	Species:	Mus musculus
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	138/370 - (37%)
Similarity:	206/370 - (55%)	Gaps:	38/370 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse   365 CNECGKSLSSSSGLQRHQRIHR----GEKAYICAECNKCFIQKSQLKTHQRIHTGEKSYKCSECE 425
            |.|||.|.|:...|.||...|:    .:|.::|..|.:.|...:||.||:|.||||:.:||..|.
  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306

Mouse   426 KSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDL 490
            |::|.|.:|:.|...|..||.:||.:|.|.|..:.:||.|.:.||||:||||.:|.::|...|.|
  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGL 371

Mouse   491 RMHQKIHTGEKPYKCSDCDKCFIQKAKLKKHQRIHTGEKPYKCSECEKCFTVVSDLRTHQKIHTG 555
            ::|.::|..|:|:||..|.|.|:|    .:|                        |.||.::|.|
  Fly   372 KLHSRLHKEERPFKCELCGKGFVQ----NQH------------------------LITHLRVHNG 408

Mouse   556 EKPYKCSECDKCFIRKANLRRHHRIHTGEKPYKCSDCGKCFIQKANLRTHERIHTGEKPYKC-EC 619
            ::.:||.:|||.|..|:|:.:|.|.|:|.||:||.:||:.|....:|::|.||||||||||| :|
  Fly   409 DRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQC 473

Mouse   620 GKSFTVGSDLRKHQKCH--TGEKPYKCSECNKCFIRKAHLRRHQRIHTG-EKPYKCSDCGKCFIQ 681
            ||.|:....|.||...|  ..::|:|||:|.|.:..:..||.|::.|.. ::|.....|..|.::
  Fly   474 GKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVR 538

Mouse   682 KANLRTHQKIHTGEK--PYKCSECDKCFIQKDHLRTHQRLHTGEK 724
            .|..:|..|..|..|  |:.|.:|.:.|..:..|:.|.|||..:|
  Fly   539 FALKKTLDKHITSHKIRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp40	NP_001344626.1	KRAB	42..82	CDD:307490
		C2H2 Zn finger	227..247	CDD:275368
		C2H2 Zn finger	255..275	CDD:275368
		COG5048	279..677	CDD:227381	122/319 (38%)
		C2H2 Zn finger	283..302	CDD:275368
		C2H2 Zn finger	310..330	CDD:275368
		C2H2 Zn finger	338..358	CDD:275368
		C2H2 Zn finger	365..385	CDD:275368	9/19 (47%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		C2H2 Zn finger	533..553	CDD:275368	3/19 (16%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	618..636	CDD:275368	7/17 (41%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	672..692	CDD:275368	5/19 (26%)
		zf-H2C2_2	684..709	CDD:316026	8/26 (31%)
		C2H2 Zn finger	700..720	CDD:275368	6/19 (32%)
		C2H2 Zn finger	728..748	CDD:275368
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	9/19 (47%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	12/23 (52%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/47 (19%)
		COG5048	<395..583	CDD:227381	74/215 (34%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	16/23 (70%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000